Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study.

Link: https://doi.org/10.3389/fgene.2019.00494
Authors: Lin, Bridget M; Nadkarni, Girish N; Tao, Ran; Graff, Mariaelisa; Fornage, Myriam; Buyske, Steven; Matise, Tara C; Highland, Heather M; Wilkens, Lynne R; Carlson, Christopher S; Park, S Lani; Setiawan, V Wendy; Ambite, Jose Luis; Heiss, Gerardo; Boerwinkle, Eric; Lin, Dan-Yu; Morris, Andrew P; Loos, Ruth J F; Kooperberg, Charles; North, Kari E; Wassel, Christina L; Franceschini, Nora

Abstract: Chronic kidney disease (CKD) is common and disproportionally burdens United States ethnic minorities. Its genetic determinants may differ by disease severity and clinical stages. To uncover genetic factors associated CKD severity among high-risk ethnic groups, we performed genome-wide association studies (GWAS) in diverse populations within the Population Architecture using Genomics and Epidemiology (PAGE) study. We assembled multi-ethnic genome-wide imputed data on CKD non-overlapping cases [4,150 mild to moderate CKD, 1,105 end-stage kidney disease (ESKD)] and non-CKD controls for up to 41,041 PAGE participants (African Americans, Hispanics/Latinos, East Asian, Native Hawaiian, and American Indians). We implemented a generalized estimating equation approach for GWAS using ancestry combined data while adjusting for age, sex, principal components, study, and ethnicity.