Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D.

Link: https://doi.org/10.1681/ASN.2021060735
Authors: Chen, Teresa K; Coca, Steven G; Estrella, Michelle M; Appel, Lawrence J; Coresh, Josef; Thiessen Philbrook, Heather; Obeid, Wassim; Fried, Linda F; Heerspink, Hiddo J L; Ix, Joachim H; Shlipak, Michael G; Kimmel, Paul L; Parikh, Chirag R; Grams, Morgan E; ,

Abstract: Higher baseline levels of soluble TNF receptors (TNFR1 and TNFR2) have been associated with progressive CKD. Whether longitudinal changes in these biomarkers of inflammation are also associated with worse kidney outcomes has been less studied. Among individuals with and without diabetes, longitudinal increases in TNFR1 and TNFR2 were each associated with progressive CKD, independent of initial biomarker level and kidney function.