Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression.

Link: https://doi.org/10.1681/ASN.0000000000000343
Authors: Schlosser, Pascal; Surapaneni, Aditya L; Borisov, Oleg; Schmidt, Insa M; Zhou, Linda; Anderson, Amanda; Deo, Rajat; Dubin, Ruth; Ganz, Peter; He, Jiang; Kimmel, Paul L; Li, Hongzhe; Nelson, Robert G; Porter, Anna C; Rahman, Mahboob; Rincon-Choles, Hernan; Shah, Vallabh; Unruh, Mark L; Vasan, Ramachandran S; Zheng, Zihe; Feldman, Harold I; Waikar, Sushrut S; Köttgen, Anna; Rhee, Eugene P; Coresh, Josef; Grams, Morgan E; ,

Abstract: Integrated analysis of proteome and metabolome identifies modules associated with CKD progression and kidney failure. Ephrin transmembrane proteins and podocyte-expressed CRIM1 and NPNT emerged as central components and warrant experimental and clinical investigation. Proteins and metabolites play crucial roles in various biological functions and are frequently interconnected through enzymatic or transport processes. This study demonstrates that integration of the proteome and metabolome can identify functions of pathophysiologic importance in kidney disease.