Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD.

Link: https://doi.org/10.2215/CJN.0000000000000463
Authors: Lee, Arthur M; Xu, Yunwen; Hu, Jian; Xiao, Rui; Hooper, Stephen R; Hartung, Erum A; Coresh, Josef; Rhee, Eugene P; Vasan, Ramachandran S; Kimmel, Paul L; Warady, Bradley A; Furth, Susan L; Denburg, Michelle R; ,

Abstract: Longitudinal untargeted metabolomics. Children with CKD have a circulating metabolome that changes over time. Understanding plasma metabolome patterns in relation to changing kidney function in pediatric CKD is important for continued research for identifying novel biomarkers, characterizing biochemical pathophysiology, and developing targeted interventions. There are a limited number of studies of longitudinal metabolomics and virtually none in pediatric CKD. We characterized longitudinal plasma metabolomic patterns associated with eGFR and UPCR in a large pediatric CKD population. Many of these metabolite signals have been associated with CKD progression, etiology, and proteinuria in previous CKD Biomarkers Consortium studies. There were also novel metabolite associations with eGFR and proteinuria detected.