Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression.

Link: https://doi.org/10.1681/ASN.0000000000000343 Authors: Schlosser, Pascal; Surapaneni, Aditya L; Borisov, Oleg; Schmidt, Insa M; Zhou, Linda; Anderson, Amanda; Deo, Rajat; Dubin, Ruth; Ganz, Peter; He, Jiang; Kimmel, Paul L; Li, Hongzhe; Nelson, Robert G; Porter, Anna C; Rahman, Mahboob; Rincon-Choles, Hernan; Shah, Vallabh; Unruh, Mark L; Vasan, Ramachandran S; Zheng, Zihe; Feldman, Harold I; Waikar, Sushrut…

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Genome-first evaluation with exome sequence and clinical data uncovers underdiagnosed genetic disorders in a large healthcare system.

Link: https://doi.org/10.1016/j.xcrm.2024.101518 Authors: Forrest, Iain S; Duffy, Áine; Park, Joshua K; Vy, Ha My T; Pasquale, Louis R; Nadkarni, Girish N; Cho, Judy H; Do, Ron Abstract: Population-based genomic screening may help diagnose individuals with disease-risk variants. Here, we perform a genome-first evaluation for nine disorders in 29,039 participants with linked exome sequences and electronic…

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A Multimodal Video-Based AI Biomarker for Aortic Stenosis Development and Progression.

Link: https://doi.org/10.1001/jamacardio.2024.0595 Authors: Oikonomou, Evangelos K; Holste, Gregory; Yuan, Neal; Coppi, Andreas; McNamara, Robert L; Haynes, Norrisa A; Vora, Amit N; Velazquez, Eric J; Li, Fan; Menon, Venu; Kapadia, Samir R; Gill, Thomas M; Nadkarni, Girish N; Krumholz, Harlan M; Wang, Zhangyang; Ouyang, David; Khera, Rohan Abstract: Aortic stenosis (AS) is a major public health…

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Utilizing large language models in breast cancer management: systematic review.

Link: https://doi.org/10.1007/s00432-024-05678-6 Authors: Sorin, Vera; Glicksberg, Benjamin S; Artsi, Yaara; Barash, Yiftach; Konen, Eli; Nadkarni, Girish N; Klang, Eyal Abstract: Despite advanced technologies in breast cancer management, challenges remain in efficiently interpreting vast clinical data for patient-specific insights. We reviewed the literature on how large language models (LLMs) such as ChatGPT might offer solutions in…

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Integrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury.

Link: https://doi.org/10.1101/2024.03.18.24304401 Authors: Anandakrishnan, Nanditha; Yi, Zhengzi; Sun, Zeguo; Liu, Tong; Haydak, Jonathan; Eddy, Sean; Jayaraman, Pushkala; DeFronzo, Stefanie; Saha, Aparna; Sun, Qian; Yang, Dai; Mendoza, Anthony; Mosoyan, Gohar; Wen, Huei Hsun; Schaub, Jennifer A; Fu, Jia; Kehrer, Thomas; Menon, Rajasree; Otto, Edgar A; Godfrey, Bradley; Suarez-Farinas, Mayte; Leffters, Sean; Twumasi, Akosua; Meliambro, Kristin; Charney,…

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A Multimodality Video-Based AI Biomarker For Aortic Stenosis Development And Progression.

Link: https://doi.org/10.1101/2023.09.28.23296234 Authors: Oikonomou, Evangelos K; Holste, Gregory; Yuan, Neal; Coppi, Andreas; McNamara, Robert L; Haynes, Norrisa; Vora, Amit N; Velazquez, Eric J; Li, Fan; Menon, Venu; Kapadia, Samir R; Gill, Thomas M; Nadkarni, Girish N; Krumholz, Harlan M; Wang, Zhangyang; Ouyang, David; Khera, Rohan Abstract: Aortic stenosis (AS) is a major public health challenge…

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Large language models: a primer and gastroenterology applications.

Link: https://doi.org/10.1177/17562848241227031 Authors: Shahab, Omer; El Kurdi, Bara; Shaukat, Aasma; Nadkarni, Girish; Soroush, Ali Abstract: Over the past year, the emergence of state-of-the-art large language models (LLMs) in tools like ChatGPT has ushered in a rapid acceleration in artificial intelligence (AI) innovation. These powerful AI models can generate tailored and high-quality text responses to instructions…

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Automated Diagnostic Reports from Images of Electrocardiograms at the Point-of-Care.

Link: https://doi.org/10.1101/2024.02.17.24302976 Authors: Khunte, Akshay; Sangha, Veer; Oikonomou, Evangelos K; Dhingra, Lovedeep S; Aminorroaya, Arya; Coppi, Andreas; Shankar, Sumukh Vasisht; Mortazavi, Bobak J; Bhatt, Deepak L; Krumholz, Harlan M; Nadkarni, Girish N; Vaid, Akhil; Khera, Rohan Abstract: Timely and accurate assessment of electrocardiograms (ECGs) is crucial for diagnosing, triaging, and clinically managing patients. Current workflows…

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