A foundation model for clinician-centered drug repurposing.

Link: https://doi.org/10.1101/2023.03.19.23287458 Authors: Huang, Kexin; Chandak, Payal; Wang, Qianwen; Havaldar, Shreyas; Vaid, Akhil; Leskovec, Jure; Nadkarni, Girish; Glicksberg, Benjamin S; Gehlenborg, Nils; Zitnik, Marinka Abstract: Drug repurposing – identifying new therapeutic uses for approved drugs – is often serendipitous and opportunistic, expanding the use of drugs for new diseases. The clinical utility of drug repurposing…

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Development and Validation of a Policy Tree Approach for Optimizing Intravenous Fluids in Critically Ill Patients with Sepsis and Acute Kidney Injury.

Link: https://doi.org/10.1101/2024.08.06.24311556 Authors: Oh, Wonsuk; Takkavatakarn, Kullaya; Kittrell, Hannah; Shawwa, Khaled; Gomez, Hernando; Sawant, Ashwin S; Tandon, Pranai; Kumar, Gagan; Sterling, Michael; Hofer, Ira; Chan, Lili; Oropello, John; Kohli-Seth, Roopa; Charney, Alexander W; Kraft, Monica; Kovatch, Patricia; Kellum, John A; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Intravenous fluids are mainstay of management of acute kidney…

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A foundational transformer leveraging full night, multichannel sleep study data accurately classifies sleep stages.

Link: https://doi.org/10.1101/2024.08.02.24311417 Authors: Fox, Benjamin; Jiang, Joy; Wickramaratne, Sajila; Kovatch, Patricia; Suarez-Farinas, Mayte; Shah, Neomi A; Parekh, Ankit; Nadkarni, Girish N Abstract: To investigate whether a foundational transformer model using 8-hour, multichannel data from polysomnograms can outperform existing artificial intelligence (AI) methods for sleep stage classification. We utilized the Sleep Heart Health Study (SHHS) visits…

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Racial, Ethnic, and Sex Differences in Incidence-Based Mortality of Aggregate Upper Gastrointestinal Cancers.

Link: https://doi.org/10.14309/ctg.0000000000000745 Authors: Malick, Alyyah; Ferris, Jennifer S; Hur, Chin; Abrams, Julian A; Soroush, Ali Abstract: Current strategies for upper gastrointestinal (UGI) cancer screening primarily target cancer-specific risk, with the strongest focus on esophageal adenocarcinoma (EAC). However, all UGI cancers are amendable to screening and early detection with an upper endoscopic examination. This study assesses…

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Role of artificial intelligence in critical care nutrition support and research.

Link: https://doi.org/10.1002/ncp.11194 Authors: Kittrell, Hannah D; Shaikh, Ahmed; Adintori, Peter A; McCarthy, Paul; Kohli-Seth, Roopa; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Nutrition plays a key role in the comprehensive care of critically ill patients. Determining optimal nutrition strategy, however, remains a subject of intense debate. Artificial intelligence (AI) applications are becoming increasingly common in medicine,…

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Evaluating prompt engineering on GPT-3.5’s performance in USMLE-style medical calculations and clinical scenarios generated by GPT-4.

Link: https://doi.org/10.1038/s41598-024-66933-x Authors: Patel, Dhavalkumar; Raut, Ganesh; Zimlichman, Eyal; Cheetirala, Satya Narayan; Nadkarni, Girish N; Glicksberg, Benjamin S; Apakama, Donald U; Bell, Elijah J; Freeman, Robert; Timsina, Prem; Klang, Eyal Abstract: This study was designed to assess how different prompt engineering techniques, specifically direct prompts, Chain of Thought (CoT), and a modified CoT approach, influence…

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Closing the gap between open-source and commercial large language models for medical evidence summarization.

Link: https://doi.org/arXiv:2408.00588v1 Authors: Zhang, Gongbo; Jin, Qiao; Zhou, Yiliang; Wang, Song; Idnay, Betina R; Luo, Yiming; Park, Elizabeth; Nestor, Jordan G; Spotnitz, Matthew E; Soroush, Ali; Campion, Thomas; Lu, Zhiyong; Weng, Chunhua; Peng, Yifan Abstract: Large language models (LLMs) hold great promise in summarizing medical evidence. Most recent studies focus on the application of proprietary…

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Advancing Genetic Testing in Kidney Diseases: Report From a National Kidney Foundation Working Group.

Link: https://doi.org/S0272-6386(24)00871-0 Authors: Franceschini, Nora; Feldman, David L; Berg, Jonathan S; Besse, Whitney; Chang, Alexander R; Dahl, Neera K; Gbadegesin, Rasheed; Pollak, Martin R; Rasouly, Hila Milo; Smith, Richard J H; Winkler, Cheryl A; Gharavi, Ali G; , Abstract: About 37 million people in the United States have chronic kidney disease, a disease that encompasses…

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