Posts Tagged ‘Bioinformatics’
Derivation and independent validation of kidneyintelX.dkd: A prognostic test for the assessment of diabetic kidney disease progression.
Link: https://doi.org/10.1111/dom.15273 Authors: Nadkarni, Girish N; Stapleton, Sharon; Takale, Dipti; Edwards, Katherine; Moran, Kara; Mosoyan, Gohar; Hansen, Michael K; Donovan, Michael J; Heerspink, Hiddo J L; Fleming, Fergus; Coca, Steven G Abstract: To develop and validate an updated version of KidneyIntelX (kidneyintelX.dkd) to stratify patients for risk of progression of diabetic kidney disease (DKD) stages…
Read MoreCertain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease.
Link: https://doi.org/S0085-2538(23)00559-8 Authors: Claus, Laura R; Chen, Chuan; Stallworth, Jennifer; Turner, Joshua L; Slaats, Gisela G; Hawks, Alexandra L; Mabillard, Holly; Senum, Sarah R; Srikanth, Sujata; Flanagan-Steet, Heather; Louie, Raymond J; Silver, Josh; Lerner-Ellis, Jordan; Morel, Chantal; Mighton, Chloe; Sleutels, Frank; van Slegtenhorst, Marjon; van Ham, Tjakko; Brooks, Alice S; Dorresteijn, Eiske M; Barakat, Tahsin…
Read MoreA study of gene expression in the living human brain.
Link: https://doi.org/10.1101/2023.04.21.23288916 Authors: Liharska, Lora E; Park, You Jeong; Ziafat, Kimia; Wilkins, Lillian; Silk, Hannah; Linares, Lisa M; Vornholt, Eric; Sullivan, Brendan; Cohen, Vanessa; Kota, Prashant; Feng, Claudia; Cheng, Esther; Moya, Emily; Thompson, Ryan C; Johnson, Jessica S; Rieder, Marysia-Kolbe; Huang, Jia; Scarpa, Joseph; Hashemi, Alice; Polanco, Jairo; Levin, Matthew A; Nadkarni, Girish N; Sebra,…
Read MoreReversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells.
Link: https://doi.org/10.1007/s00125-023-05960-1 Authors: Shah, Ruchi; Spektor, Tanya M; Weisenberger, Daniel J; Ding, Hui; Patil, Rameshwar; Amador, Cynthia; Song, Xue-Ying; Chun, Steven T; Inzalaco, Jake; Turjman, Sue; Ghiam, Sean; Jeong-Kim, Jiho; Tolstoff, Sasha; Yampolsky, Sabina V; Sawant, Onkar B; Rabinowitz, Yaron S; Maguen, Ezra; Hamrah, Pedram; Svendsen, Clive N; Saghizadeh, Mehrnoosh; Ljubimova, Julia Y; Kramerov, Andrei…
Read MoreGenome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.
Link: https://doi.org/10.1038/s41588-023-01420-z Authors: Klarin, Derek; Devineni, Poornima; Sendamarai, Anoop K; Angueira, Anthony R; Graham, Sarah E; Shen, Ying H; Levin, Michael G; Pirruccello, James P; Surakka, Ida; Karnam, Purushotham R; Roychowdhury, Tanmoy; Li, Yanming; Wang, Minxian; Aragam, Krishna G; Paruchuri, Kaavya; Zuber, Verena; Shakt, Gabrielle E; Tsao, Noah L; Judy, Renae L; Vy, Ha My…
Read MoreProteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection.
Link: https://doi.org/10.1038/s43856-023-00307-8 Authors: Paranjpe, Ishan; Jayaraman, Pushkala; Su, Chen-Yang; Zhou, Sirui; Chen, Steven; Thompson, Ryan; Del Valle, Diane Marie; Kenigsberg, Ephraim; Zhao, Shan; Jaladanki, Suraj; Chaudhary, Kumardeep; Ascolillo, Steven; Vaid, Akhil; Gonzalez-Kozlova, Edgar; Kauffman, Justin; Kumar, Arvind; Paranjpe, Manish; Hagan, Ross O; Kamat, Samir; Gulamali, Faris F; Xie, Hui; Harris, Joceyln; Patel, Manishkumar; Argueta, Kimberly;…
Read MorePolygenic prediction of preeclampsia and gestational hypertension.
Link: https://doi.org/10.1038/s41591-023-02374-9 Authors: Honigberg, Michael C; Truong, Buu; Khan, Raiyan R; Xiao, Brenda; Bhatta, Laxmi; Vy, Ha My T; Guerrero, Rafael F; Schuermans, Art; Selvaraj, Margaret Sunitha; Patel, Aniruddh P; Koyama, Satoshi; Cho, So Mi Jemma; Vellarikkal, Shamsudheen Karuthedath; Trinder, Mark; Urbut, Sarah M; Gray, Kathryn J; Brumpton, Ben M; Patil, Snehal; Zöllner, Sebastian; Antopia,…
Read MoreGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
Link: https://doi.org/10.1007/s00125-023-05922-7 Authors: Li, Josephine H; Brenner, Laura N; Kaur, Varinderpal; Figueroa, Katherine; Schroeder, Philip; Huerta-Chagoya, Alicia; , ; , ; Udler, Miriam S; Leong, Aaron; Mercader, Josep M; Florez, Jose C Abstract: Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes.…
Read MoreA machine learning approach to determine resilience utilizing wearable device data: analysis of an observational cohort.
Link: https://doi.org/10.1093/jamiaopen/ooad029 Authors: Hirten, Robert P; Suprun, Maria; Danieletto, Matteo; Zweig, Micol; Golden, Eddye; Pyzik, Renata; Kaur, Sparshdeep; Helmus, Drew; Biello, Anthony; Landell, Kyle; Rodrigues, Jovita; Bottinger, Erwin P; Keefer, Laurie; Charney, Dennis; Nadkarni, Girish N; Suarez-Farinas, Mayte; Fayad, Zahi A Abstract: To assess whether an individual’s degree of psychological resilience can be determined from…
Read MoreA machine learning model identifies patients in need of autoimmune disease testing using electronic health records.
Link: https://doi.org/10.1038/s41467-023-37996-7 Authors: Forrest, Iain S; Petrazzini, Ben O; Duffy, Áine; Park, Joshua K; O’Neal, Anya J; Jordan, Daniel M; Rocheleau, Ghislain; Nadkarni, Girish N; Cho, Judy H; Blazer, Ashira D; Do, Ron Abstract: Systemic autoimmune rheumatic diseases (SARDs) can lead to irreversible damage if left untreated, yet these patients often endure long diagnostic journeys…
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