Posts Tagged ‘Bioinformatics’
Large language models in medicine: A review of current clinical trials across healthcare applications.
Link: https://doi.org/10.1371/journal.pdig.0000662 Authors: Omar, Mahmud; Nadkarni, Girish N; Klang, Eyal; Glicksberg, Benjamin S Abstract: This review analyzes current clinical trials investigating large language models’ (LLMs) applications in healthcare. We identified 27 trials (5 published and 22 ongoing) across 4 main clinical applications: patient care, data handling, decision support, and research assistance. Our analysis reveals diverse…
Read MoreA strategy for cost-effective large language model use at health system-scale.
Link: https://doi.org/10.1038/s41746-024-01315-1 Authors: Klang, Eyal; Apakama, Donald; Abbott, Ethan E; Vaid, Akhil; Lampert, Joshua; Sakhuja, Ankit; Freeman, Robert; Charney, Alexander W; Reich, David; Kraft, Monica; Nadkarni, Girish N; Glicksberg, Benjamin S Abstract: Large language models (LLMs) can optimize clinical workflows; however, the economic and computational challenges of their utilization at the health system scale are…
Read MoreAssessing Retrieval-Augmented Large Language Model Performance in Emergency Department ICD-10-CM Coding Compared to Human Coders.
Link: https://doi.org/10.1101/2024.10.15.24315526 Authors: Klang, Eyal; Tessler, Idit; Apakama, Donald U; Abbott, Ethan; Glicksberg, Benjamin S; Arnold, Monique; Moses, Akini; Sakhuja, Ankit; Soroush, Ali; Charney, Alexander W; Reich, David L; McGreevy, Jolion; Gavin, Nicholas; Carr, Brendan; Freeman, Robert; Nadkarni, Girish N Abstract: Accurate medical coding is essential for clinical and administrative purposes but complicated, time-consuming, and…
Read MoreThe Role of Kt/V and Creatinine clearance on Assisting Optimization of Serum Phosphorus Levels among Patients on PD.
Link: https://doi.org/10.34067/KID.0000000618 Authors: Uribarri, Jaime; Guedes, Murilo; Diaz Bessone, Maria Ines; Chan, Lili; De La Torre, Andres; Mermelstein, Ariella; Garcia-Garcia, Guillermo; Raimann, Jochen; Moraes, Thyago; Peters, Vincent; Konings, Stijn; Farrell, Doug; Sharma, Shuchita; Guinsburg, Adrian; Kotanko, Peter Abstract: Hyperphosphatemia is associated with poor outcome and is still very common in peritoneal dialysis (PD) patients. Since…
Read MoreMeasurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study.
Link: https://doi.org/S1198-743X(24)00432-4 Authors: Swank, Zoe; Borberg, Ella; Chen, Yulu; Senussi, Yasmeen; Chalise, Sujata; Manickas-Hill, Zachary; Yu, Xu G; Li, Jonathan Z; Alter, Galit; Henrich, Timothy J; Kelly, J Daniel; Hoh, Rebecca; Goldberg, Sarah A; Deeks, Steven G; Martin, Jeffrey N; Peluso, Michael J; Talla, Aarthi; Li, Xiaojun; Skene, Peter; Bumol, Thomas F; Torgerson, Troy R;…
Read MoreDerivation, external and clinical validation of a deep learning approach for detecting intracranial hypertension.
Link: https://doi.org/10.1038/s41746-024-01227-0 Authors: Gulamali, Faris; Jayaraman, Pushkala; Sawant, Ashwin S; Desman, Jacob; Fox, Benjamin; Chang, Annette; Soong, Brian Y; Arivazagan, Naveen; Reynolds, Alexandra S; Duong, Son Q; Vaid, Akhil; Kovatch, Patricia; Freeman, Robert; Hofer, Ira S; Sakhuja, Ankit; Dangayach, Neha S; Reich, David S; Charney, Alexander W; Nadkarni, Girish N Abstract: Increased intracranial pressure (ICP)…
Read MoreEchocardiographic Predictors of Readiness for Double Switch Operation and Postoperative Ejection Fraction in Patients With Congenitally Corrected Transposition of the Great Arteries Undergoing Left Ventricular Retraining.
Link: https://doi.org/S0894-7317(24)00438-3 Authors: Duong, Son Q; Ho, Deborah; Punn, Rajesh; Sganga, Danielle; Mainwaring, Richard; Ma, Michael; Hanley, Frank L; Lee, Kyong-Jin; Maskatia, Shiraz A Abstract: In patients with congenitally corrected transposition of the great arteries (ccTGA), assessment of readiness for the double switch operation (DSO) after pulmonary arterial band (PAB) placement involves cardiac magnetic resonance…
Read MoreAssessing GPT-4 multimodal performance in radiological image analysis.
Link: https://doi.org/10.1007/s00330-024-11035-5 Authors: Brin, Dana; Sorin, Vera; Barash, Yiftach; Konen, Eli; Glicksberg, Benjamin S; Nadkarni, Girish N; Klang, Eyal Abstract: This study aims to assess the performance of a multimodal artificial intelligence (AI) model capable of analyzing both images and textual data (GPT-4V), in interpreting radiological images. It focuses on a range of modalities, anatomical…
Read MoreMultimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population.
Link: https://doi.org/10.1038/s41746-024-01218-1 Authors: Jiang, Joy; Thi Vy, Ha My; Charney, Alexander; Kovatch, Patricia; Reddy, Vivek; Jayaraman, Pushkala; Do, Ron; Khera, Rohan; Chugh, Sumeet; Bhatt, Deepak L; Vaid, Akhil; Lampert, Joshua; Nadkarni, Girish Nitin Abstract: Congenital long QT syndrome (LQTS) diagnosis is complicated by limited genetic testing at scale, low prevalence, and normal QT corrected interval…
Read MoreDevelopment and Validation of a Policy Tree Approach for Optimizing Intravenous Fluids in Critically Ill Patients with Sepsis and Acute Kidney Injury.
Link: https://doi.org/10.1101/2024.08.06.24311556 Authors: Oh, Wonsuk; Takkavatakarn, Kullaya; Kittrell, Hannah; Shawwa, Khaled; Gomez, Hernando; Sawant, Ashwin S; Tandon, Pranai; Kumar, Gagan; Sterling, Michael; Hofer, Ira; Chan, Lili; Oropello, John; Kohli-Seth, Roopa; Charney, Alexander W; Kraft, Monica; Kovatch, Patricia; Kellum, John A; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Intravenous fluids are mainstay of management of acute kidney…
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