Posts Tagged ‘Bioinformatics’
Autoencoders for sample size estimation for fully connected neural network classifiers.
Link: https://doi.org/10.1038/s41746-022-00728-0 Authors: Gulamali, Faris F; Sawant, Ashwin S; Kovatch, Patricia; Glicksberg, Benjamin; Charney, Alexander; Nadkarni, Girish N; Oermann, Eric Abstract: Sample size estimation is a crucial step in experimental design but is understudied in the context of deep learning. Currently, estimating the quantity of labeled data needed to train a classifier to a desired…
Read MoreCannabis Use and CKD: Epidemiological Associations and Mendelian Randomization.
Link: https://doi.org/10.1016/j.xkme.2022.100582 Authors: Dellepiane, Sergio; Paranjpe, Ishan; Rajagopal, Madhumitha; Kamat, Samir; O’Hagan, Ross; Gulamali, Faris; Rein, Joshua L; Charney, Alexander W; Do, Ron; Coca, Steven; Glicksberg, Benjamin S; Nadkarni, Girish N Abstract: The association between cannabis use and chronic kidney disease (CKD) is controversial. We aimed to assess association of CKD with cannabis use in…
Read MoreShort-term prediction of coronary artery disease using serum metabolomic patterns.
Link: https://doi.org/10.1016/j.ahjo.2022.100232 Authors: Petrazzini, Ben Omega; Vaid, Akhil; Park, Joshua K; Marquez-Luna, Carla; Vy, Ha My; Saha, Aparna; Chaudhary, Kumardeep; Cho, Judy; Chan, Lili; Argulian, Edgar; Narula, Jagat; Nadkarni, Girish; Do, Ron Abstract:
Read MoreGenome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.
Link: https://doi.org/10.1038/s41467-022-34216-6 Authors: Levin, Michael G; Tsao, Noah L; Singhal, Pankhuri; Liu, Chang; Vy, Ha My T; Paranjpe, Ishan; Backman, Joshua D; Bellomo, Tiffany R; Bone, William P; Biddinger, Kiran J; Hui, Qin; Dikilitas, Ozan; Satterfield, Benjamin A; Yang, Yifan; Morley, Michael P; Bradford, Yuki; Burke, Megan; Reza, Nosheen; Charest, Brian; , ; Judy, Renae…
Read MoreMendelian gene identification through mouse embryo viability screening.
Link: https://doi.org/10.1186/s13073-022-01118-7 Authors: Cacheiro, Pilar; Westerberg, Carl Henrik; Mager, Jesse; Dickinson, Mary E; Nutter, Lauryl M J; Muñoz-Fuentes, Violeta; Hsu, Chih-Wei; Van den Veyver, Ignatia B; Flenniken, Ann M; McKerlie, Colin; Murray, Stephen A; Teboul, Lydia; Heaney, Jason D; Lloyd, K C Kent; Lanoue, Louise; Braun, Robert E; White, Jacqueline K; Creighton, Amie K; Laurin,…
Read MoreCross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.
Link: https://doi.org/10.1161/CIRCULATIONAHA.122.059675 Authors: Thibord, Florian; Klarin, Derek; Brody, Jennifer A; Chen, Ming-Huei; Levin, Michael G; Chasman, Daniel I; Goode, Ellen L; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L; Nadkarni, Girish N; de Vries, Paul S; Cuellar-Partida, Gabriel; Wolford, Brooke N; Pattee, Jack W; Kooperberg, Charles;…
Read MoreProteomic Characterization of Acute Kidney Injury in Patients Hospitalized with SARS-CoV2 Infection.
Link: https://doi.org/10.1101/2021.12.09.21267548 Authors: Paranjpe, Ishan; Jayaraman, Pushkala; Su, Chen-Yang; Zhou, Sirui; Chen, Steven; Thompson, Ryan; Del Valle, Diane Marie; Kenigsberg, Ephraim; Zhao, Shan; Jaladanki, Suraj; Chaudhary, Kumardeep; Ascolillo, Steven; Vaid, Akhil; Kumar, Arvind; Kozlova, Edgar; Paranjpe, Manish; O’Hagan, Ross; Kamat, Samir; Gulamali, Faris F; Kauffman, Justin; Xie, Hui; Harris, Joceyln; Patel, Manishkumar; Argueta, Kimberly; Batchelor,…
Read MoreA first update on mapping the human genetic architecture of COVID-19.
Link: https://doi.org/10.1038/s41586-022-04826-7 Authors: , Abstract:
Read MoreStudyU: A Platform for Designing and Conducting Innovative Digital N-of-1 Trials.
Link: https://doi.org/10.2196/35884 Authors: Konigorski, Stefan; Wernicke, Sarah; Slosarek, Tamara; Zenner, Alexander M; Strelow, Nils; Ruether, Darius F; Henschel, Florian; Manaswini, Manisha; Pottbäcker, Fabian; Edelman, Jonathan A; Owoyele, Babajide; Danieletto, Matteo; Golden, Eddye; Zweig, Micol; Nadkarni, Girish N; Böttinger, Erwin Abstract: N-of-1 trials are the gold standard study design to evaluate individual treatment effects and derive…
Read MoreEpigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.
Link: https://doi.org/10.1038/s41588-022-01097-w Authors: Liu, Hongbo; Doke, Tomohito; Guo, Dong; Sheng, Xin; Ma, Ziyuan; Park, Joseph; Vy, Ha My T; Nadkarni, Girish N; Abedini, Amin; Miao, Zhen; Palmer, Matthew; Voight, Benjamin F; Li, Hongzhe; Brown, Christopher D; Ritchie, Marylyn D; Shu, Yan; Susztak, Katalin Abstract: More than 800 million people suffer from kidney disease, yet the…
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