Posts Tagged ‘Bioinformatics’
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
Link: https://doi.org/10.1038/s41467-020-15706-x Authors: Ntalla, Ioanna; Weng, Lu-Chen; Cartwright, James H; Hall, Amelia Weber; Sveinbjornsson, Gardar; Tucker, Nathan R; Choi, Seung Hoan; Chaffin, Mark D; Roselli, Carolina; Barnes, Michael R; Mifsud, Borbala; Warren, Helen R; Hayward, Caroline; Marten, Jonathan; Cranley, James J; Concas, Maria Pina; Gasparini, Paolo; Boutin, Thibaud; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Araujo,…
Read MoreMapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017.
Link: https://doi.org/10.1038/s41591-020-0807-6 Authors: , Abstract: A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant…
Read MoreHuman and mouse essentiality screens as a resource for disease gene discovery.
Link: https://doi.org/10.1038/s41467-020-14284-2 Authors: Cacheiro, Pilar; Muñoz-Fuentes, Violeta; Murray, Stephen A; Dickinson, Mary E; Bucan, Maja; Nutter, Lauryl M J; Peterson, Kevin A; Haselimashhadi, Hamed; Flenniken, Ann M; Morgan, Hugh; Westerberg, Henrik; Konopka, Tomasz; Hsu, Chih-Wei; Christiansen, Audrey; Lanza, Denise G; Beaudet, Arthur L; Heaney, Jason D; Fuchs, Helmut; Gailus-Durner, Valerie; Sorg, Tania; Prochazka, Jan; Novosadova,…
Read MoreThe epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Link: https://doi.org/10.1038/s41467-019-14082-5 Authors: Inda, Maria Carmen; Joshi, Suhasini; Wang, Tai; Bolaender, Alexander; Gandu, Srinivasa; Koren Iii, John; Che, Alicia Yue; Taldone, Tony; Yan, Pengrong; Sun, Weilin; Uddin, Mohammad; Panchal, Palak; Riolo, Matthew; Shah, Smit; Barlas, Afsar; Xu, Ke; Chan, Lon Yin L; Gruzinova, Alexandra; Kishinevsky, Sarah; Studer, Lorenz; Fossati, Valentina; Noggle, Scott A; White, Julie…
Read MoreTarget genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Link: https://doi.org/10.1038/s41588-019-0504-x Authors: Tin, Adrienne; Marten, Jonathan; Halperin Kuhns, Victoria L; Li, Yong; Wuttke, Matthias; Kirsten, Holger; Sieber, Karsten B; Qiu, Chengxiang; Gorski, Mathias; Yu, Zhi; Giri, Ayush; Sveinbjornsson, Gardar; Li, Man; Chu, Audrey Y; Hoppmann, Anselm; O’Connor, Luke J; Prins, Bram; Nutile, Teresa; Noce, Damia; Akiyama, Masato; Cocca, Massimiliano; Ghasemi, Sahar; van der Most,…
Read MoreA catalog of genetic loci associated with kidney function from analyses of a million individuals.
Link: https://doi.org/10.1038/s41588-019-0407-x Authors: Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B; Feitosa, Mary F; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar; Xu, Yizhe; Horn, Katrin; Noce, Damia; van der…
Read MoreGenetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study.
Link: https://doi.org/10.3389/fgene.2019.00494 Authors: Lin, Bridget M; Nadkarni, Girish N; Tao, Ran; Graff, Mariaelisa; Fornage, Myriam; Buyske, Steven; Matise, Tara C; Highland, Heather M; Wilkens, Lynne R; Carlson, Christopher S; Park, S Lani; Setiawan, V Wendy; Ambite, Jose Luis; Heiss, Gerardo; Boerwinkle, Eric; Lin, Dan-Yu; Morris, Andrew P; Loos, Ruth J F; Kooperberg, Charles; North, Kari…
Read MorePatient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.
Link: https://doi.org/S1934-5909(18)30554-X Authors: Hu, Wenxiang; Jiang, Chunjie; Guan, Dongyin; Dierickx, Pieterjan; Zhang, Rong; Moscati, Arden; Nadkarni, Girish N; Steger, David J; Loos, Ruth J F; Hu, Cheng; Jia, Weiping; Soccio, Raymond E; Lazar, Mitchell A Abstract: Thiazolidinedione drugs (TZDs) target the transcriptional activity of peroxisome proliferator activated receptor γ (PPARγ) to reverse insulin resistance in…
Read MoreAdiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.
Link: https://doi.org/10.1136/bmj.k5301 Authors: Chang, Alex R; Grams, Morgan E; Ballew, Shoshana H; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D; Roderick, Paul J; Valdivielso, Jose M; Visseren, Frank L J; Zhang, Luxia; Gansevoort, Ron…
Read MoreChange in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies.
Link: https://doi.org/S2213-8587(18)30313-9 Authors: Coresh, Josef; Heerspink, Hiddo J L; Sang, Yingying; Matsushita, Kunihiro; Arnlov, Johan; Astor, Brad C; Black, Corri; Brunskill, Nigel J; Carrero, Juan-Jesus; Feldman, Harold I; Fox, Caroline S; Inker, Lesley A; Ishani, Areef; Ito, Sadayoshi; Jassal, Simerjot; Konta, Tsuneo; Polkinghorne, Kevan; Romundstad, Solfrid; Solbu, Marit D; Stempniewicz, Nikita; Stengel, Benedicte; Tonelli, Marcello;…
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