Automated Transformation of Unstructured Cardiovascular Diagnostic Reports into Structured Datasets Using Sequentially Deployed Large Language Models.

Link: https://doi.org/10.1101/2024.10.08.24315035 Authors: Shankar, Sumukh Vasisht; Dhingra, Lovedeep S; Aminorroaya, Arya; Adejumo, Philip; Nadkarni, Girish N; Xu, Hua; Brandt, Cynthia; Oikonomou, Evangelos K; Pedroso, Aline F; Khera, Rohan Abstract: Rich data in cardiovascular diagnostic testing are often sequestered in unstructured reports, with the necessity of manual abstraction limiting their use in real-time applications in patient…

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A foundation model for clinician-centered drug repurposing.

Link: https://doi.org/10.1038/s41591-024-03233-x Authors: Huang, Kexin; Chandak, Payal; Wang, Qianwen; Havaldar, Shreyas; Vaid, Akhil; Leskovec, Jure; Nadkarni, Girish N; Glicksberg, Benjamin S; Gehlenborg, Nils; Zitnik, Marinka Abstract: Drug repurposing-identifying new therapeutic uses for approved drugs-is often a serendipitous and opportunistic endeavour to expand the use of drugs for new diseases. The clinical utility of drug-repurposing artificial…

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Derivation, external and clinical validation of a deep learning approach for detecting intracranial hypertension.

Link: https://doi.org/10.1038/s41746-024-01227-0 Authors: Gulamali, Faris; Jayaraman, Pushkala; Sawant, Ashwin S; Desman, Jacob; Fox, Benjamin; Chang, Annette; Soong, Brian Y; Arivazagan, Naveen; Reynolds, Alexandra S; Duong, Son Q; Vaid, Akhil; Kovatch, Patricia; Freeman, Robert; Hofer, Ira S; Sakhuja, Ankit; Dangayach, Neha S; Reich, David S; Charney, Alexander W; Nadkarni, Girish N Abstract: Increased intracranial pressure (ICP)…

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Echocardiographic Predictors of Readiness for Double Switch Operation and Postoperative Ejection Fraction in Patients With Congenitally Corrected Transposition of the Great Arteries Undergoing Left Ventricular Retraining.

Link: https://doi.org/S0894-7317(24)00438-3 Authors: Duong, Son Q; Ho, Deborah; Punn, Rajesh; Sganga, Danielle; Mainwaring, Richard; Ma, Michael; Hanley, Frank L; Lee, Kyong-Jin; Maskatia, Shiraz A Abstract: In patients with congenitally corrected transposition of the great arteries (ccTGA), assessment of readiness for the double switch operation (DSO) after pulmonary arterial band (PAB) placement involves cardiac magnetic resonance…

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Assessing GPT-4 multimodal performance in radiological image analysis.

Link: https://doi.org/10.1007/s00330-024-11035-5 Authors: Brin, Dana; Sorin, Vera; Barash, Yiftach; Konen, Eli; Glicksberg, Benjamin S; Nadkarni, Girish N; Klang, Eyal Abstract: This study aims to assess the performance of a multimodal artificial intelligence (AI) model capable of analyzing both images and textual data (GPT-4V), in interpreting radiological images. It focuses on a range of modalities, anatomical…

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Multimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population.

Link: https://doi.org/10.1038/s41746-024-01218-1 Authors: Jiang, Joy; Thi Vy, Ha My; Charney, Alexander; Kovatch, Patricia; Reddy, Vivek; Jayaraman, Pushkala; Do, Ron; Khera, Rohan; Chugh, Sumeet; Bhatt, Deepak L; Vaid, Akhil; Lampert, Joshua; Nadkarni, Girish Nitin Abstract: Congenital long QT syndrome (LQTS) diagnosis is complicated by limited genetic testing at scale, low prevalence, and normal QT corrected interval…

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Development and Validation of a Policy Tree Approach for Optimizing Intravenous Fluids in Critically Ill Patients with Sepsis and Acute Kidney Injury.

Link: https://doi.org/10.1101/2024.08.06.24311556 Authors: Oh, Wonsuk; Takkavatakarn, Kullaya; Kittrell, Hannah; Shawwa, Khaled; Gomez, Hernando; Sawant, Ashwin S; Tandon, Pranai; Kumar, Gagan; Sterling, Michael; Hofer, Ira; Chan, Lili; Oropello, John; Kohli-Seth, Roopa; Charney, Alexander W; Kraft, Monica; Kovatch, Patricia; Kellum, John A; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Intravenous fluids are mainstay of management of acute kidney…

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