Posts Tagged ‘Cardiology’
Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial.
Link: https://doi.org/10.1001/jamanetworkopen.2022.1048 Authors: Nadkarni, Girish N; Fei, Kezhen; Ramos, Michelle A; Hauser, Diane; Bagiella, Emilia; Ellis, Stephen B; Sanderson, Saskia; Scott, Stuart A; Sabin, Tatiana; Madden, Ebony; Cooper, Richard; Pollak, Martin; Calman, Neil; Bottinger, Erwin P; Horowitz, Carol R Abstract: Risk variants in the apolipoprotein L1 (APOL1 [OMIM 603743]) gene on chromosome 22 are common…
Read MorePost-operative Morbidity and Mortality After Fontan Procedure in Patients with Heterotaxy and Other Situs Anomalies.
Link: https://doi.org/10.1007/s00246-021-02804-w Authors: Duong, Son Q; Zaniletti, Isabella; Lopez, Leo; Sutherland, Scott M; Shin, Andrew Y; Collins, R Thomas Abstract: Heterotaxy is a complex, multisystem disorder associated with single ventricle heart disease and decreased survival. Ciliary dysfunction is common in heterotaxy and other situs abnormalities (H/SA) and may increase post-operative complications. We hypothesized that patients…
Read MoreIdentification of patients at risk of new onset heart failure: Utilizing a large statewide health information exchange to train and validate a risk prediction model.
Link: https://doi.org/10.1371/journal.pone.0260885 Authors: Duong, Son Q; Zheng, Le; Xia, Minjie; Jin, Bo; Liu, Modi; Li, Zhen; Hao, Shiying; Alfreds, Shaun T; Sylvester, Karl G; Widen, Eric; Teuteberg, Jeffery J; McElhinney, Doff B; Ling, Xuefeng B Abstract: New-onset heart failure (HF) is associated with poor prognosis and high healthcare utilization. Early identification of patients at increased…
Read MoreDevelopment of a machine learning model using electrocardiogram signals to improve acute pulmonary embolism screening.
Link: https://doi.org/10.1093/ehjdh/ztab101 Authors: Somani, Sulaiman S; Honarvar, Hossein; Narula, Sukrit; Landi, Isotta; Lee, Shawn; Khachatoorian, Yeraz; Rehmani, Arsalan; Kim, Andrew; De Freitas, Jessica K; Teng, Shelly; Jaladanki, Suraj; Kumar, Arvind; Russak, Adam; Zhao, Shan P; Freeman, Robert; Levin, Matthew A; Nadkarni, Girish N; Kagen, Alexander C; Argulian, Edgar; Glicksberg, Benjamin S Abstract: Clinical scoring systems…
Read MoreDeciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses.
Link: https://doi.org/10.1038/s41467-021-26771-1 Authors: Contreras-Trujillo, Humberto; Eerdeng, Jiya; Akre, Samir; Jiang, Du; Contreras, Jorge; Gala, Basia; Vergel-Rodriguez, Mary C; Lee, Yeachan; Jorapur, Aparna; Andreasian, Areen; Harton, Lisa; Bramlett, Charles S; Nogalska, Anna; Xiao, Gang; Lee, Jae-Woong; Chan, Lai N; Müschen, Markus; Merchant, Akil A; Lu, Rong Abstract: Cellular heterogeneity is a major cause of treatment resistance…
Read MoreDerivation and Validation of Genome-Wide Polygenic Score for Ischemic Heart Failure.
Link: https://doi.org/10.1161/JAHA.121.021916 Authors: Paranjpe, Ishan; Tsao, Noah L; De Freitas, Jessica K; Judy, Renae; Chaudhary, Kumardeep; Forrest, Iain S; Jaladanki, Suraj K; Paranjpe, Manish; Sharma, Pranav; , ; , ; Glicksberg, Benjamin S; Narula, Jagat; Do, Ron; Damrauer, Scott M; Nadkarni, Girish N Abstract:
Read MoreContrastive learning improves critical event prediction in COVID-19 patients.
Link: https://doi.org/10.1016/j.patter.2021.100389 Authors: Wanyan, Tingyi; Honarvar, Hossein; Jaladanki, Suraj K; Zang, Chengxi; Naik, Nidhi; Somani, Sulaiman; De Freitas, Jessica K; Paranjpe, Ishan; Vaid, Akhil; Zhang, Jing; Miotto, Riccardo; Wang, Zhangyang; Nadkarni, Girish N; Zitnik, Marinka; Azad, Ariful; Wang, Fei; Ding, Ying; Glicksberg, Benjamin S Abstract: Deep learning (DL) models typically require large-scale, balanced training data…
Read MoreUsing Deep-Learning Algorithms to Simultaneously Identify Right and Left Ventricular Dysfunction From the Electrocardiogram.
Link: https://doi.org/S1936-878X(21)00627-6 Authors: Vaid, Akhil; Johnson, Kipp W; Badgeley, Marcus A; Somani, Sulaiman S; Bicak, Mesude; Landi, Isotta; Russak, Adam; Zhao, Shan; Levin, Matthew A; Freeman, Robert S; Charney, Alexander W; Kukar, Atul; Kim, Bette; Danilov, Tatyana; Lerakis, Stamatios; Argulian, Edgar; Narula, Jagat; Nadkarni, Girish N; Glicksberg, Benjamin S Abstract: This study sought to develop…
Read MoreActivation of STAT3 signaling pathway in the kidney of COVID-19 patients.
Link: https://doi.org/10.1007/s40620-021-01173-0 Authors: Salem, Fadi; Li, Xue Zhu; Hindi, Judy; Casablanca, Nitzy Munoz; Zhong, Fang; El Jamal, Siraj M; Haroon Al Rasheed, Mohamed Rizwan; Li, Li; Lee, Kyung; Chan, Lili; He, John Cijiang Abstract: Acute kidney injury is common in patients with COVID-19, however mechanisms of kidney injury remain unclear. Since cytokine storm is likely…
Read MoreDevelopment and validation of techniques for phenotyping ST-elevation myocardial infarction encounters from electronic health records.
Link: https://doi.org/10.1093/jamiaopen/ooab068 Authors: Somani, Sulaiman; Yoffie, Stephen; Teng, Shelly; Havaldar, Shreyas; Nadkarni, Girish N; Zhao, Shan; Glicksberg, Benjamin S Abstract: Classifying hospital admissions into various acute myocardial infarction phenotypes in electronic health records (EHRs) is a challenging task with strong research implications that remains unsolved. To our knowledge, this study is the first study to…
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