Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk.

By Amir Safavi | October 24, 2023 |

Link: https://doi.org/10.1016/j.ebiom.2023.104831 Authors: van Gerwen, Maaike; Colicino, Elena; Guan, Haibin; Dolios, Georgia; Nadkarni, Girish N; Vermeulen, Roel C H; Wolff, Mary S; Arora, Manish; Genden, Eric M; Petrick, Lauren M Abstract: Although per- and polyfluoroalkyl substances (PFAS) exposure is a potential contributor to the increasing thyroid cancer trend, limited studies have investigated the association between…

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Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.2337/dc21-1395 Authors: DiCorpo, Daniel; LeClair, Jessica; Cole, Joanne B; Sarnowski, Chloé; Ahmadizar, Fariba; Bielak, Lawrence F; Blokstra, Anneke; Bottinger, Erwin P; Chaker, Layal; Chen, Yii-Der I; Chen, Ye; de Vries, Paul S; Faquih, Tariq; Ghanbari, Mohsen; Gudmundsdottir, Valborg; Guo, Xiuqing; Hasbani, Natalie R; Ibi, Dorina; Ikram, M Arfan; Kavousi, Maryam; Leonard, Hampton L; Leong,…

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.

By Amir Safavi | May 12, 2022 |

Link: https://doi.org/10.1038/s41588-022-01058-3 Authors: Mahajan, Anubha; Spracklen, Cassandra N; Zhang, Weihua; Ng, Maggie C Y; Petty, Lauren E; Kitajima, Hidetoshi; Yu, Grace Z; Rüeger, Sina; Speidel, Leo; Kim, Young Jin; Horikoshi, Momoko; Mercader, Josep M; Taliun, Daniel; Moon, Sanghoon; Kwak, Soo-Heon; Robertson, Neil R; Rayner, Nigel W; Loh, Marie; Kim, Bong-Jo; Chiou, Joshua; Miguel-Escalada, Irene; Della…

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Genetic discovery and risk characterization in type 2 diabetes across diverse populations.

By Amir Safavi | March 9, 2021 |

Link: https://doi.org/10.1016/j.xhgg.2021.100029 Authors: Polfus, Linda M; Darst, Burcu F; Highland, Heather; Sheng, Xin; Ng, Maggie C Y; Below, Jennifer E; Petty, Lauren; Bien, Stephanie; Sim, Xueling; Wang, Wei; Fontanillas, Pierre; Patel, Yesha; , ; , ; , ; Preuss, Michael; Schurmann, Claudia; Du, Zhaohui; Lu, Yingchang; Rhie, Suhn K; Mercader, Joseph M; Tusie-Luna, Teresa; González-Villalpando,…

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Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.

By Amir Safavi | June 23, 2020 |

Link: https://doi.org/10.1371/journal.pmed.1003132 Authors: Dapas, Matthew; Lin, Frederick T J; Nadkarni, Girish N; Sisk, Ryan; Legro, Richard S; Urbanek, Margrit; Hayes, M Geoffrey; Dunaif, Andrea Abstract: Polycystic ovary syndrome (PCOS) is a common, complex genetic disorder affecting up to 15% of reproductive-age women worldwide, depending on the diagnostic criteria applied. These diagnostic criteria are based on…

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