Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.

Link: https://doi.org/10.7326/M24-0737 Authors: Erlandson, Kristine M; Geng, Linda N; Selvaggi, Caitlin A; Thaweethai, Tanayott; Chen, Peter; Erdmann, Nathan B; Goldman, Jason D; Henrich, Timothy J; Hornig, Mady; Karlson, Elizabeth W; Katz, Stuart D; Kim, C; Cribbs, Sushma K; Laiyemo, Adeyinka O; Letts, Rebecca; Lin, Janet Y; Marathe, Jai; Parthasarathy, Sairam; Patterson, Thomas F; Taylor, Brittany…

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Development and Validation of a Policy Tree Approach for Optimizing Intravenous Fluids in Critically Ill Patients with Sepsis and Acute Kidney Injury.

Link: https://doi.org/10.1101/2024.08.06.24311556 Authors: Oh, Wonsuk; Takkavatakarn, Kullaya; Kittrell, Hannah; Shawwa, Khaled; Gomez, Hernando; Sawant, Ashwin S; Tandon, Pranai; Kumar, Gagan; Sterling, Michael; Hofer, Ira; Chan, Lili; Oropello, John; Kohli-Seth, Roopa; Charney, Alexander W; Kraft, Monica; Kovatch, Patricia; Kellum, John A; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Intravenous fluids are mainstay of management of acute kidney…

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A foundation model for clinician-centered drug repurposing.

Link: https://doi.org/10.1101/2023.03.19.23287458 Authors: Huang, Kexin; Chandak, Payal; Wang, Qianwen; Havaldar, Shreyas; Vaid, Akhil; Leskovec, Jure; Nadkarni, Girish; Glicksberg, Benjamin S; Gehlenborg, Nils; Zitnik, Marinka Abstract: Drug repurposing – identifying new therapeutic uses for approved drugs – is often serendipitous and opportunistic, expanding the use of drugs for new diseases. The clinical utility of drug repurposing…

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A foundational transformer leveraging full night, multichannel sleep study data accurately classifies sleep stages.

Link: https://doi.org/10.1101/2024.08.02.24311417 Authors: Fox, Benjamin; Jiang, Joy; Wickramaratne, Sajila; Kovatch, Patricia; Suarez-Farinas, Mayte; Shah, Neomi A; Parekh, Ankit; Nadkarni, Girish N Abstract: To investigate whether a foundational transformer model using 8-hour, multichannel data from polysomnograms can outperform existing artificial intelligence (AI) methods for sleep stage classification. We utilized the Sleep Heart Health Study (SHHS) visits…

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Role of artificial intelligence in critical care nutrition support and research.

Link: https://doi.org/10.1002/ncp.11194 Authors: Kittrell, Hannah D; Shaikh, Ahmed; Adintori, Peter A; McCarthy, Paul; Kohli-Seth, Roopa; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Nutrition plays a key role in the comprehensive care of critically ill patients. Determining optimal nutrition strategy, however, remains a subject of intense debate. Artificial intelligence (AI) applications are becoming increasingly common in medicine,…

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Artificial intelligence-guided detection of under-recognized cardiomyopathies on point-of-care cardiac ultrasound: a multi-center study.

Link: https://doi.org/10.1101/2024.03.10.24304044 Authors: Oikonomou, Evangelos K; Vaid, Akhil; Holste, Gregory; Coppi, Andreas; McNamara, Robert L; Baloescu, Cristiana; Krumholz, Harlan M; Wang, Zhangyang; Apakama, Donald J; Nadkarni, Girish N; Khera, Rohan Abstract: Point-of-care ultrasonography (POCUS) enables cardiac imaging at the bedside and in communities but is limited by abbreviated protocols and variation in quality. We developed…

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Accurate prediction of neurologic changes in critically ill infants using pose AI.

Link: https://doi.org/10.1101/2024.04.17.24305953 Authors: Gleason, Alec; Richter, Florian; Beller, Nathalia; Arivazhagan, Naveen; Feng, Rui; Holmes, Emma; Glicksberg, Benjamin S; Morton, Sarah U; La Vega-Talbott, Maite; Fields, Madeline; Guttmann, Katherine; Nadkarni, Girish N; Richter, Felix Abstract: Infant alertness and neurologic changes can reflect life-threatening pathology but are assessed by exam, which can be intermittent and subjective. Reliable,…

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Assessing calibration and bias of a deployed machine learning malnutrition prediction model within a large healthcare system.

Link: https://doi.org/10.1038/s41746-024-01141-5 Authors: Liou, Lathan; Scott, Erick; Parchure, Prathamesh; Ouyang, Yuxia; Egorova, Natalia; Freeman, Robert; Hofer, Ira S; Nadkarni, Girish N; Timsina, Prem; Kia, Arash; Levin, Matthew A Abstract: Malnutrition is a frequently underdiagnosed condition leading to increased morbidity, mortality, and healthcare costs. The Mount Sinai Health System (MSHS) deployed a machine learning model (MUST-Plus)…

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