A novel method leveraging time series data to improve subphenotyping and application in critically ill patients with COVID-19.

Link: https://doi.org/S0933-3657(23)00264-6 Authors: Oh, Wonsuk; Jayaraman, Pushkala; Tandon, Pranai; Chaddha, Udit S; Kovatch, Patricia; Charney, Alexander W; Glicksberg, Benjamin S; Nadkarni, Girish N Abstract: Computational subphenotyping, a data-driven approach to understanding disease subtypes, is a prominent topic in medical research. Numerous ongoing studies are dedicated to developing advanced computational subphenotyping methods for cross-sectional data. However,…

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Timing of invasive mechanical ventilation and death in critically ill adults with COVID-19: A multicenter cohort study.

Link: https://doi.org/10.1371/journal.pone.0285748 Authors: Green, Adam; Rachoin, Jean-Sebastien; Schorr, Christa; Dellinger, Phil; Casey, Jonathan D; Park, Isabel; Gupta, Shruti; Baron, Rebecca M; Shaefi, Shahzad; Hunter, Krystal; Leaf, David E; , Abstract: To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. The data for…

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Analysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes: Results From Clinical Trials in Organ Transplantation-17.

Link: https://doi.org/10.1097/TP.0000000000002026 Authors: Faddoul, Geovani; Nadkarni, Girish N; Bridges, Nancy D; Goebel, Jens; Hricik, Donald E; Formica, Richard; Menon, Madhav C; Morrison, Yvonne; Murphy, Barbara; Newell, Kenneth; Nickerson, Peter; Poggio, Emilio D; Rush, David; Heeger, Peter S; , Abstract: An early posttransplant biomarker/surrogate marker for kidney allograft loss has the potential to guide targeted interventions.…

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Unmasking Fracture Risk in Type 2 Diabetes: The Association of Longitudinal Glycemic Hemoglobin Level and Medications.

Link: https://doi.org/10.1210/clinem/dgab882 Authors: Wang, Bowen; Wang, Zehai; Poundarik, Atharva A; Zaki, Mohammed J; Bockman, Richard S; Glicksberg, Benjamin S; Nadkarni, Girish N; Vashishth, Deepak Abstract: Fracture risk is underestimated in people with type 2 diabetes (T2D). To investigate the longitudinal relationship of glycated hemoglobin (HbA1c) and common medications on fracture risk in people with T2D.…

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Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis.

Link: https://doi.org/10.1001/jama.2023.17002 Authors: , ; Grams, Morgan E; Coresh, Josef; Matsushita, Kunihiro; Ballew, Shoshana H; Sang, Yingying; Surapaneni, Aditya; Alencar de Pinho, Natalia; Anderson, Amanda; Appel, Lawrence J; Ärnlöv, Johan; Azizi, Fereidoun; Bansal, Nisha; Bell, Samira; Bilo, Henk J G; Brunskill, Nigel J; Carrero, Juan J; Chadban, Steve; Chalmers, John; Chen, Jing; Ciemins, Elizabeth; Cirillo,…

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Artificial Intelligence and Machine Learning in Perioperative Acute Kidney Injury.

Link: https://doi.org/S2949-8139(22)00001-5 Authors: Takkavatakarn, Kullaya; Hofer, Ira S Abstract: Acute kidney injury (AKI) is a common complication after a surgery, especially in cardiac and aortic procedures, and has a significant impact on morbidity and mortality. Early identification of high-risk patients and providing effective prevention and therapeutic approach are the main strategies for reducing the possibility…

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Incidence, prevalence and mortality of chronic periaortitis: a population-based study.

Link: https://doi.org/10.55563/clinexprheumatol/0v8l4j Authors: Koster, Matthew J; Ghaffar, Umar; Duong, Stephanie Q; Crowson, Cynthia S; Burke, Michelle M; Viers, Boyd R; Potretzke, Aaron M; Bjarnason, Haraldur; Warrington, Kenneth J Abstract: To evaluate the epidemiology, presentation and outcomes of patients with chronic periaortitis from 1998 through 2018. An inception cohort of patients with incident chronic periaortitis from…

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