Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients.

Link: https://doi.org/10.2215/CJN.10640918
Authors: Chauhan, Kinsuk; Pattharanitima, Pattharawin; Patel, Niralee; Duffy, Aine; Saha, Aparna; Chaudhary, Kumardeep; Debnath, Neha; Van Vleck, Tielman; Chan, Lili; Nadkarni, Girish N; Coca, Steven G

Abstract: Hypernatremia is common in hospitalized, critically ill patients. Although there are no clear guidelines on sodium correction rate for hypernatremia, some studies suggest a reduction rate not to exceed 0.5 mmol/L per hour. However, the data supporting this recommendation and the optimal rate of hypernatremia correction in hospitalized adults are unclear. We did not find any evidence that rapid correction of hypernatremia is associated with a higher risk for mortality, seizure, alteration of consciousness, and/or cerebral edema in critically ill adult patients with either admission or hospital-acquired hypernatremia.