Posts by Amir Safavi
Polygenic prediction of preeclampsia and gestational hypertension.
Link: https://doi.org/10.1038/s41591-023-02374-9 Authors: Honigberg, Michael C; Truong, Buu; Khan, Raiyan R; Xiao, Brenda; Bhatta, Laxmi; Vy, Ha My T; Guerrero, Rafael F; Schuermans, Art; Selvaraj, Margaret Sunitha; Patel, Aniruddh P; Koyama, Satoshi; Cho, So Mi Jemma; Vellarikkal, Shamsudheen Karuthedath; Trinder, Mark; Urbut, Sarah M; Gray, Kathryn J; Brumpton, Ben M; Patil, Snehal; Zöllner, Sebastian; Antopia,…
Read MoreGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.
Link: https://doi.org/10.1007/s00125-023-05922-7 Authors: Li, Josephine H; Brenner, Laura N; Kaur, Varinderpal; Figueroa, Katherine; Schroeder, Philip; Huerta-Chagoya, Alicia; , ; , ; Udler, Miriam S; Leong, Aaron; Mercader, Josep M; Florez, Jose C Abstract: Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes.…
Read MoreA machine learning approach to determine resilience utilizing wearable device data: analysis of an observational cohort.
Link: https://doi.org/10.1093/jamiaopen/ooad029 Authors: Hirten, Robert P; Suprun, Maria; Danieletto, Matteo; Zweig, Micol; Golden, Eddye; Pyzik, Renata; Kaur, Sparshdeep; Helmus, Drew; Biello, Anthony; Landell, Kyle; Rodrigues, Jovita; Bottinger, Erwin P; Keefer, Laurie; Charney, Dennis; Nadkarni, Girish N; Suarez-Farinas, Mayte; Fayad, Zahi A Abstract: To assess whether an individual’s degree of psychological resilience can be determined from…
Read MoreDepression and anxiety are associated with an increased risk of infection, revision, and reoperation following total hip or knee arthroplasty.
Link: https://doi.org/10.1302/0301-620X.105B5.BJJ-2022-1123.R1 Authors: Harmer, Joshua R; Wyles, Cody C; Duong, Stephanie Q; Morgan Iii, Robert J; Maradit-Kremers, Hilal; Abdel, Matthew P Abstract: The aim of this study was to determine the prevalence of depressive and anxiety disorders prior to total hip (THA) and total knee arthroplasty (TKA) and to assess their impact on the rates…
Read MoreQuantitative prediction of right ventricular and size and function from the electrocardiogram.
Link: https://doi.org/10.1101/2023.04.25.23289130 Authors: Duong, Son Q; Vaid, Akhil; Vy, Ha My Thi; Butler, Liam R; Lampert, Joshua; Pass, Robert H; Charney, Alexander W; Narula, Jagat; Khera, Rohan; Greenspan, Hayit; Gelb, Bruce D; Do, Ron; Nadkarni, Girish Abstract: Right ventricular ejection fraction (RVEF) and end-diastolic volume (RVEDV) are not readily assessed through traditional modalities. Deep-learning enabled…
Read MoreA machine learning model identifies patients in need of autoimmune disease testing using electronic health records.
Link: https://doi.org/10.1038/s41467-023-37996-7 Authors: Forrest, Iain S; Petrazzini, Ben O; Duffy, Áine; Park, Joshua K; O’Neal, Anya J; Jordan, Daniel M; Rocheleau, Ghislain; Nadkarni, Girish N; Cho, Judy H; Blazer, Ashira D; Do, Ron Abstract: Systemic autoimmune rheumatic diseases (SARDs) can lead to irreversible damage if left untreated, yet these patients often endure long diagnostic journeys…
Read MoreJoint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes.
Link: https://doi.org/10.2215/CJN.0000000000000156 Authors: Vasquez-Rios, George; Oh, Wonsuk; Lee, Samuel; Bhatraju, Pavan; Mansour, Sherry G; Moledina, Dennis G; Gulamali, Faris F; Siew, Edward D; Garg, Amit X; Sarder, Pinaki; Chinchilli, Vernon M; Kaufman, James S; Hsu, Chi-Yuan; Liu, Kathleen D; Kimmel, Paul L; Go, Alan S; Wurfel, Mark M; Himmelfarb, Jonathan; Parikh, Chirag R; Coca, Steven…
Read MoreInhaled Corticosteroids Rarely Prescribed at Emergency Department Discharge Despite Low Rates of Follow-Up Care.
Link: https://doi.org/S0736-4679(23)00062-8 Authors: Kligler, Sophie Karwoska; Vargas-Torres, Carmen; Abbott, Ethan E; Lin, Michelle P Abstract: Guidelines recommend an inhaled corticosteroid (ICS) prescription on emergency department (ED) discharge after acute asthma exacerbations. We sought to identify rates and predictors of ICS prescription at ED discharge. Secondary outcomes included ICS prescription rates in a high-risk subgroup, outpatient…
Read MoreProteomic Characterization of Acute Kidney Injury in Patients Hospitalized with SARS-CoV2 Infection.
Link: https://doi.org/10.21203/rs.3.rs-2379226/v1 Authors: Nadkami, Girish; Paranjpe, Ishan; Jayaraman, Pushkala; Su, Chen-Yang; Zhou, Sirui; Chen, Steven; Valle, Diane Del; Thompson, Ryan; Kenigsberg, Ephraim; Zhao, Shan; Jaladanki, Suraj; Chaudhary, Kumardeep; Ascolillo, Steven; Vaid, Akhil; Gonzalez-Kozlova, Edgar; Kumar, Arvind; Paranjpe, Manish; O’Hagan, Ross; Kamat, Samir; Gulamali, Faris; Kauffman, Justin; Xie, Hui; Harris, Joceyln; Patel, Manishkumar; Argueta, Kimberly; Batchelor,…
Read MoreRandomized Trial of Anticoagulation Strategies for Noncritically Ill Patients Hospitalized With COVID-19.
Link: https://doi.org/S0735-1097(23)04527-8 Authors: Stone, Gregg W; Farkouh, Michael E; Lala, Anuradha; Tinuoye, Elizabeth; Dressler, Ovidiu; Moreno, Pedro R; Palacios, Igor F; Goodman, Shaun G; Esper, Rodrigo B; Abizaid, Alexandre; Varade, Deepak; Betancur, Juan F; Ricalde, Alejandro; Payro, Gerardo; Castellano, José María; Hung, Ivan F N; Nadkarni, Girish N; Giustino, Gennaro; Godoy, Lucas C; Feinman, Jason;…
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