4research
Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension.
Link: https://doi.org/S1551-7144(22)00139-2 Authors: Eadon, Michael T; Cavanaugh, Kerri L; Orlando, Lori A; Christian, David; Chakraborty, Hrishikesh; Steen-Burrell, Kady-Ann; Merrill, Peter; Seo, Janet; Hauser, Diane; Singh, Rajbir; Beasley, Cherry Maynor; Fuloria, Jyotsna; Kitzman, Heather; Parker, Alexander S; Ramos, Michelle; Ong, Henry H; Elwood, Erica N; Lynch, Sheryl E; Clermont, Sabrina; Cicali, Emily J; Starostik, Petr; Pratt,…
Read MoreModular Fluted Tapered Stems for Periprosthetic Femoral Fractures: Excellent Results in 171 Cases.
Link: https://doi.org/10.2106/JBJS.21.01168 Authors: Hannon, Charles P; Sheehan, Kevin P; Duong, Stephanie Q; Yuan, Brandon J; Lewallen, David G; Berry, Daniel J; Abdel, Matthew P Abstract: Modular fluted tapered (MFT) stems have advanced treatment of Vancouver B2 and B3 periprosthetic femoral fractures, but series to date have been limited with respect to cohort size and follow-up…
Read MoreProteomic Analyses Unveil Actionable Disease Pathways in COVID-19: A Step Toward Targeted Therapies.
Link: https://doi.org/10.1016/j.jacbts.2022.03.011 Authors: Vasquez-Rios, George; Nadkarni, Girish N Abstract:
Read MoreEvaluation of a machine learning approach utilizing wearable data for prediction of SARS-CoV-2 infection in healthcare workers.
Link: https://doi.org/10.1093/jamiaopen/ooac041 Authors: Hirten, Robert P; Tomalin, Lewis; Danieletto, Matteo; Golden, Eddye; Zweig, Micol; Kaur, Sparshdeep; Helmus, Drew; Biello, Anthony; Pyzik, Renata; Bottinger, Erwin P; Keefer, Laurie; Charney, Dennis; Nadkarni, Girish N; Suarez-Farinas, Mayte; Fayad, Zahi A Abstract: To determine whether a machine learning model can detect SARS-CoV-2 infection from physiological metrics collected from wearable…
Read MoreHispanic ethnicity and mortality among critically ill patients with COVID-19.
Link: https://doi.org/10.1371/journal.pone.0268022 Authors: Ricardo, Ana C; Chen, Jinsong; Toth-Manikowski, Stephanie M; Meza, Natalie; Joo, Min; Gupta, Shruti; Lazarous, Deepa G; Leaf, David E; Lash, James P; , Abstract: Hispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Whether this…
Read MoreRising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades.
Link: https://doi.org/10.1136/annrheumdis-2022-222276 Authors: Duarte-García, Alí; Hocaoglu, Mehmet; Valenzuela-Almada, Maria; Osei-Onomah, Shirley-Ann; Dabit, Jesse Y; Sanchez-Rodriguez, Alain; Duong, Stephanie Q; Giblon, Rachel E; Langenfeld, Hannah E; Alarcón, Graciela S; Helmick, Charles G; Crowson, Cynthia S Abstract: To determine the trends in incidence, prevalence and mortality of systemic lupus erythematosus (SLE) in a US population over four…
Read MoreMulti-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Link: https://doi.org/10.1038/s41588-022-01058-3 Authors: Mahajan, Anubha; Spracklen, Cassandra N; Zhang, Weihua; Ng, Maggie C Y; Petty, Lauren E; Kitajima, Hidetoshi; Yu, Grace Z; Rüeger, Sina; Speidel, Leo; Kim, Young Jin; Horikoshi, Momoko; Mercader, Josep M; Taliun, Daniel; Moon, Sanghoon; Kwak, Soo-Heon; Robertson, Neil R; Rayner, Nigel W; Loh, Marie; Kim, Bong-Jo; Chiou, Joshua; Miguel-Escalada, Irene; Della…
Read MoreGenome-first recall of healthy individuals by polygenic risk score reveals differences in coronary artery calcium.
Link: https://doi.org/S0002-8703(22)00081-3 Authors: Forrest, Iain S; Chan, Lili; Chaudhary, Kumardeep; Saha, Aparna; Wen, Huei Hsun; Cepin, Cristina Liriano; Marquez-Luna, Carla; Rocheleau, Ghislain; Cho, Judy; Narula, Jagat; Nadkarni, Girish N; Do, Ron Abstract: Genetic risk for coronary artery disease (CAD) is commonly measured with polygenic risk scores (PRS); yet, the relationship of atherosclerotic burden with PRS…
Read MoreArtificial intelligence-enabled decision support in nephrology.
Link: https://doi.org/10.1038/s41581-022-00562-3 Authors: Loftus, Tyler J; Shickel, Benjamin; Ozrazgat-Baslanti, Tezcan; Ren, Yuanfang; Glicksberg, Benjamin S; Cao, Jie; Singh, Karandeep; Chan, Lili; Nadkarni, Girish N; Bihorac, Azra Abstract: Kidney pathophysiology is often complex, nonlinear and heterogeneous, which limits the utility of hypothetical-deductive reasoning and linear, statistical approaches to diagnosis and treatment. Emerging evidence suggests that artificial…
Read MoreAssociation of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease.
Link: https://doi.org/S0272-6386(22)00577-7 Authors: Sapa, Hima; Gutiérrez, Orlando M; Shlipak, Michael G; Katz, Ronit; Ix, Joachim H; Sarnak, Mark J; Cushman, Mary; Rhee, Eugene P; Kimmel, Paul L; Vasan, Ramachandran S; Schrauben, Sarah J; Feldman, Harold I; Seegmiller, Jesse C; Brunengraber, Henri; Hostetter, Thomas H; Schelling, Jeffrey R; , Abstract: Cardiovascular disease (CVD) is a major…
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