4research
Post-operative urinary retention is impacted by neuromuscular block reversal agent choice: A retrospective cohort study in US hospital setting.
Link: https://doi.org/S0952-8180(23)00294-5 Authors: Bash, Lori D; Turzhitsky, Vladimir; Mark, Robert J; Hofer, Ira S; Weingarten, Toby N Abstract: Perioperative neuromuscular blocking agents are pharmacologically reversed to minimize complications associated with residual neuromuscular block. Neuromuscular block reversal with anticholinesterases (e.g., neostigmine) require coadministration of an anticholinergic agent (e.g., glycopyrrolate) to mitigate muscarinic activity; however, sugammadex, devoid…
Read MoreEffects of Mirikizumab on Histologic Resolution of Crohn’s Disease in a Randomized Controlled Phase 2 Trial.
Link: https://doi.org/10.1016/j.cgh.2023.11.010 Authors: Magro, Fernando; Protic, Marijana; De Hertogh, Gert; Chan, Lai Shan; Pollack, Paul; Jairath, Vipul; Carlier, Hilde; Hon, Emily; Feagan, Brian G; Harpaz, Noam; Pai, Rish; Reinisch, Walter Abstract: Histologic evaluation of mucosal healing in Crohn’s disease is an evolving treatment target. We evaluated histologic outcomes for mirikizumab efficacy and associations with endoscopic…
Read MoreDevelopment of the ehive Digital Health App: Protocol for a Centralized Research Platform.
Link: https://doi.org/10.2196/49204 Authors: Hirten, Robert P; Danieletto, Matteo; Landell, Kyle; Zweig, Micol; Golden, Eddye; Orlov, Georgy; Rodrigues, Jovita; Alleva, Eugenia; Ensari, Ipek; Bottinger, Erwin; Nadkarni, Girish N; Fuchs, Thomas J; Fayad, Zahi A Abstract: The increasing use of smartphones, wearables, and connected devices has enabled the increasing application of digital technologies for research. Remote digital…
Read MoreGenome-Wide Polygenic Risk Score for CKD in Individuals with APOL1 High-Risk Genotypes.
Link: https://doi.org/10.2215/CJN.0000000000000379 Authors: Vy, Ha My T; Coca, Steven G; Sawant, Ashwin; Sakhuja, Ankit; Gutierrez, Orlando M; Cooper, Richard; Loos, Ruth J F; Horowitz, Carol R; Do, Ron; Nadkarni, Girish N Abstract:
Read MoreReversal of neuromuscular block by sugammadex is associated with less postoperative respiratory dysfunction in the PACU compared with neostigmine: a retrospective study.
Link: https://doi.org/S0007-0912(23)00551-2 Authors: Lee, Andrew; Grogan, Tristan; Gabel, Eilon; Hofer, Ira S Abstract:
Read MoreValidation of a convolutional neural network that reliably identifies electromyographic compound motor action potentials following train-of-four stimulation: an algorithm development experimental study.
Link: https://doi.org/10.1016/j.bjao.2023.100236 Authors: Epstein, Richard H; Perez, Olivia F; Hofer, Ira S; Renew, J Ross; Brull, Sorin J; Nemes, Réka Abstract: International guidelines recommend quantitative neuromuscular monitoring when administering neuromuscular blocking agents. The train-of-four count is important for determining the depth of block and appropriate reversal agents and doses. However, identifying valid compound motor action…
Read MorePeripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV2 Infection.
Link: https://doi.org/10.1101/2023.10.25.23297469 Authors: Jayaraman, Pushkala; Rajagopal, Madhumitha; Paranjpe, Ishan; Liharska, Lora; Suarez-Farinas, Mayte; Thompson, Ryan; Del Valle, Diane Marie; Beckmann, Noam; Oh, Wonsuk; Gulamali, Faris F; Kauffman, Justin; Gonzalez-Kozlova, Edgar; Dellepiane, Sergio; Vasquez-Rios, George; Vaid, Akhil; Jiang, Joy; Chen, Annie; Sakhuja, Ankit; Chen, Steven; Kenigsberg, Ephraim; He, John Cijiang; Coca, Steven G; Chan, Lili; Schadt,…
Read MorePer- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk.
Link: https://doi.org/10.1016/j.ebiom.2023.104831 Authors: van Gerwen, Maaike; Colicino, Elena; Guan, Haibin; Dolios, Georgia; Nadkarni, Girish N; Vermeulen, Roel C H; Wolff, Mary S; Arora, Manish; Genden, Eric M; Petrick, Lauren M Abstract: Although per- and polyfluoroalkyl substances (PFAS) exposure is a potential contributor to the increasing thyroid cancer trend, limited studies have investigated the association between…
Read MoreCirculating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD.
Link: https://doi.org/10.2215/CJN.0000000000000318 Authors: Lee, Arthur M; Xu, Yunwen; Hooper, Stephen R; Abraham, Alison G; Hu, Jian; Xiao, Rui; Matheson, Matthew B; Brunson, Celina; Rhee, Eugene P; Coresh, Josef; Vasan, Ramachandran S; Schrauben, Sarah; Kimmel, Paul L; Warady, Bradley A; Furth, Susan L; Hartung, Erum A; Denburg, Michelle R; , Abstract: Children with CKD are at…
Read MoreDevelopment and Validation of a Formative Assessment Tool for Nephrology Fellows’ Clinical Reasoning.
Link: https://doi.org/10.2215/CJN.0000000000000315 Authors: Boyle, Suzanne M; Martindale, James; Parsons, Andrew S; Sozio, Stephen M; Hilburg, Rachel; Bahrainwala, Jehan; Chan, Lili; Stern, Lauren D; Warburton, Karen M Abstract: Diagnostic errors are commonly driven by failures in clinical reasoning. Deficits in clinical reasoning are common among graduate medical learners, including nephrology fellows. We created and validated an…
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