Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.

Link: https://doi.org/10.1038/s41467-022-34216-6 Authors: Levin, Michael G; Tsao, Noah L; Singhal, Pankhuri; Liu, Chang; Vy, Ha My T; Paranjpe, Ishan; Backman, Joshua D; Bellomo, Tiffany R; Bone, William P; Biddinger, Kiran J; Hui, Qin; Dikilitas, Ozan; Satterfield, Benjamin A; Yang, Yifan; Morley, Michael P; Bradford, Yuki; Burke, Megan; Reza, Nosheen; Charest, Brian; , ; Judy, Renae…

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Criteria for Early Pacemaker Implantation in Patients With Postoperative Heart Block After Congenital Heart Surgery.

Link: https://doi.org/10.1161/CIRCEP.122.011145 Authors: Duong, Son Q; Shi, Yuan; Giacone, Heather; Navarre, Brittany M; Gal, Dana B; Han, Brian; Sganga, Danielle; Ma, Michael; Reddy, Charitha D; Shin, Andrew Y; Kwiatkowski, David M; Dubin, Anne M; Scheinker, David; Algaze, Claudia A Abstract: Guidelines recommend observation for atrioventricular node recovery until postoperative days (POD) 7 to 10 before…

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Survival After Out-of-Hospital Cardiac Arrest: The Role of Racial Residential Segregation.

Link: https://doi.org/10.1007/s11524-022-00691-x Authors: Abbott, Ethan E; Buckler, David G; Hsu, Jesse Y; Jacoby, Sara F; Abella, Benjamin S; Richardson, Lynne D; Carr, Brendan G; Zebrowski, Alexis M Abstract: Racial and racialized economic residential segregation has been empirically associated with outcomes across multiple health conditions but not yet explored in relation to out-of-hospital cardiac arrest (OHCA).…

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Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19.

Link: https://doi.org/10.1161/CIRCOUTCOMES.122.008942 Authors: Vasbinder, Alexi; Meloche, Chelsea; Azam, Tariq U; Anderson, Elizabeth; Catalan, Tonimarie; Shadid, Husam; Berlin, Hanna; Pan, Michael; O’Hayer, Patrick; Padalia, Kishan; Blakely, Pennelope; Khaleel, Ibrahim; Michaud, Erinleigh; Huang, Yiyuan; Zhao, Lili; Pop-Busui, Rodica; Gupta, Shruti; Eagle, Kim; Leaf, David E; Hayek, Salim S; , Abstract: Preexisting cardiovascular disease (CVD) is perceived as…

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Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.

Link: https://doi.org/10.1161/CIRCULATIONAHA.122.059675 Authors: Thibord, Florian; Klarin, Derek; Brody, Jennifer A; Chen, Ming-Huei; Levin, Michael G; Chasman, Daniel I; Goode, Ellen L; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L; Nadkarni, Girish N; de Vries, Paul S; Cuellar-Partida, Gabriel; Wolford, Brooke N; Pattee, Jack W; Kooperberg, Charles;…

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Enhancing convolutional neural network predictions of electrocardiograms with left ventricular dysfunction using a novel sub-waveform representation.

Link: https://doi.org/10.1016/j.cvdhj.2022.07.074 Authors: Honarvar, Hossein; Agarwal, Chirag; Somani, Sulaiman; Vaid, Akhil; Lampert, Joshua; Wanyan, Tingyi; Reddy, Vivek Y; Nadkarni, Girish N; Miotto, Riccardo; Zitnik, Marinka; Wang, Fei; Glicksberg, Benjamin S Abstract: Electrocardiogram (ECG) deep learning (DL) has promise to improve the outcomes of patients with cardiovascular abnormalities. In ECG DL, researchers often use convolutional neural…

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Automated Determination of Left Ventricular Function Using Electrocardiogram Data in Patients on Maintenance Hemodialysis.

Link: https://doi.org/10.2215/CJN.16481221 Authors: Vaid, Akhil; Jiang, Joy J; Sawant, Ashwin; Singh, Karandeep; Kovatch, Patricia; Charney, Alexander W; Charytan, David M; Divers, Jasmin; Glicksberg, Benjamin S; Chan, Lili; Nadkarni, Girish N Abstract: Left ventricular ejection fraction is disrupted in patients on maintenance hemodialysis and can be estimated using deep learning models on electrocardiograms. Smaller sample sizes…

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Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.

Link: https://doi.org/10.1161/HYPERTENSIONAHA.122.19324 Authors: Kelly, Tanika N; Sun, Xiao; He, Karen Y; Brown, Michael R; Taliun, Sarah A Gagliano; Hellwege, Jacklyn N; Irvin, Marguerite R; Mi, Xuenan; Brody, Jennifer A; Franceschini, Nora; Guo, Xiuqing; Hwang, Shih-Jen; de Vries, Paul S; Gao, Yan; Moscati, Arden; Nadkarni, Girish N; Yanek, Lisa R; Elfassy, Tali; Smith, Jennifer A; Chung,…

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Design and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension.

Link: https://doi.org/S1551-7144(22)00139-2 Authors: Eadon, Michael T; Cavanaugh, Kerri L; Orlando, Lori A; Christian, David; Chakraborty, Hrishikesh; Steen-Burrell, Kady-Ann; Merrill, Peter; Seo, Janet; Hauser, Diane; Singh, Rajbir; Beasley, Cherry Maynor; Fuloria, Jyotsna; Kitzman, Heather; Parker, Alexander S; Ramos, Michelle; Ong, Henry H; Elwood, Erica N; Lynch, Sheryl E; Clermont, Sabrina; Cicali, Emily J; Starostik, Petr; Pratt,…

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