Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.

By Amir Safavi | July 28, 2021 |

Link: https://doi.org/10.1161/CIRCGEN.120.003300 Authors: Choi, Seung Hoan; Jurgens, Sean J; Haggerty, Christopher M; Hall, Amelia W; Halford, Jennifer L; Morrill, Valerie N; Weng, Lu-Chen; Lagerman, Braxton; Mirshahi, Tooraj; Pettinger, Mary; Guo, Xiuqing; Lin, Henry J; Alonso, Alvaro; Soliman, Elsayed Z; Kornej, Jelena; Lin, Honghuang; Moscati, Arden; Nadkarni, Girish N; Brody, Jennifer A; Wiggins, Kerri L; Cade,…

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Impact of institutional routine surveillance endomyocardial biopsy frequency in the first year on rejection and graft survival in pediatric heart transplantation.

By Amir Safavi | May 18, 2021 |

Link: https://doi.org/10.1111/petr.14035 Authors: Duong, Son Q; Zhang, Yulin; Hall, Matt; Hollander, Seth A; Thurm, Cary W; Bernstein, Daniel; Feingold, Brian; Godown, Justin; Almond, Christopher Abstract: Routine surveillance biopsy (RSB) is performed to detect asymptomatic acute rejection (AR) after heart transplantation (HT). Variation in pediatric RSB across institutions is high. We examined center-based variation in RSB…

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SGLT2 Inhibitors: Emerging Roles in the Protection Against Cardiovascular and Kidney Disease Among Diabetic Patients.

By Amir Safavi | October 28, 2020 |

Link: https://doi.org/10.2147/IJNRD.S268811 Authors: Vasquez-Rios, George; Nadkarni, Girish N Abstract: Type 2 diabetes mellitus (T2DM) is a prevalent disease with the severe clinical implications including myocardial infarction, stroke, and kidney disease. Therapies focusing on glycemic control in T2DM such as biguanides, sulfonylureas, thiazolidinediones, and insulin-based regimens have largely failed to substantially improve cardiovascular and kidney outcomes.…

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Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets.

By Amir Safavi | October 14, 2020 |

Link: https://doi.org/10.1016/j.eclinm.2020.100552 Authors: Matsushita, Kunihiro; Jassal, Simerjot K; Sang, Yingying; Ballew, Shoshana H; Grams, Morgan E; Surapaneni, Aditya; Arnlov, Johan; Bansal, Nisha; Bozic, Milica; Brenner, Hermann; Brunskill, Nigel J; Chang, Alex R; Chinnadurai, Rajkumar; Cirillo, Massimo; Correa, Adolfo; Ebert, Natalie; Eckardt, Kai-Uwe; Gansevoort, Ron T; Gutierrez, Orlando; Hadaegh, Farzad; He, Jiang; Hwang, Shih-Jen; Jafar, Tazeen…

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In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study.

By Amir Safavi | September 30, 2020 |

Link: https://doi.org/10.1136/bmj.m3513 Authors: Hayek, Salim S; Brenner, Samantha K; Azam, Tariq U; Shadid, Husam R; Anderson, Elizabeth; Berlin, Hanna; Pan, Michael; Meloche, Chelsea; Feroz, Rafey; O’Hayer, Patrick; Kaakati, Rayan; Bitar, Abbas; Padalia, Kishan; Perry, Daniel; Blakely, Pennelope; Gupta, Shruti; Shaefi, Shahzad; Srivastava, Anand; Charytan, David M; Bansal, Anip; Mallappallil, Mary; Melamed, Michal L; Shehata, Alexandre…

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Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection.

By Amir Safavi | June 8, 2020 |

Link: https://doi.org/S0735-1097(20)35552-2 Authors: Lala, Anuradha; Johnson, Kipp W; Januzzi, James L; Russak, Adam J; Paranjpe, Ishan; Richter, Felix; Zhao, Shan; Somani, Sulaiman; Van Vleck, Tielman; Vaid, Akhil; Chaudhry, Fayzan; De Freitas, Jessica K; Fayad, Zahi A; Pinney, Sean P; Levin, Matthew; Charney, Alexander; Bagiella, Emilia; Narula, Jagat; Glicksberg, Benjamin S; Nadkarni, Girish; Mancini, Donna M;…

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Machine Learning in Cardiology-Ensuring Clinical Impact Lives Up to the Hype.

By Amir Safavi | June 4, 2020 |

Link: https://doi.org/10.1177/1074248420928651 Authors: Russak, Adam J; Chaudhry, Farhan; De Freitas, Jessica K; Baron, Garrett; Chaudhry, Fayzan F; Bienstock, Solomon; Paranjpe, Ishan; Vaid, Akhil; Ali, Mohsin; Zhao, Shan; Somani, Sulaiman; Richter, Felix; Bawa, Tejeshwar; Levy, Phillip D; Miotto, Riccardo; Nadkarni, Girish N; Johnson, Kipp W; Glicksberg, Benjamin S Abstract: Despite substantial advances in the study, treatment,…

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

By Amir Safavi | May 21, 2020 |

Link: https://doi.org/10.1038/s41467-020-15706-x Authors: Ntalla, Ioanna; Weng, Lu-Chen; Cartwright, James H; Hall, Amelia Weber; Sveinbjornsson, Gardar; Tucker, Nathan R; Choi, Seung Hoan; Chaffin, Mark D; Roselli, Carolina; Barnes, Michael R; Mifsud, Borbala; Warren, Helen R; Hayward, Caroline; Marten, Jonathan; Cranley, James J; Concas, Maria Pina; Gasparini, Paolo; Boutin, Thibaud; Kolcic, Ivana; Polasek, Ozren; Rudan, Igor; Araujo,…

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