Posts Tagged ‘LLM-NLP’
Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19.
Link: https://doi.org/10.1161/CIRCOUTCOMES.122.008942 Authors: Vasbinder, Alexi; Meloche, Chelsea; Azam, Tariq U; Anderson, Elizabeth; Catalan, Tonimarie; Shadid, Husam; Berlin, Hanna; Pan, Michael; O’Hayer, Patrick; Padalia, Kishan; Blakely, Pennelope; Khaleel, Ibrahim; Michaud, Erinleigh; Huang, Yiyuan; Zhao, Lili; Pop-Busui, Rodica; Gupta, Shruti; Eagle, Kim; Leaf, David E; Hayek, Salim S; , Abstract: Preexisting cardiovascular disease (CVD) is perceived as…
Read MoreVisual Analytics to Leverage Anesthesia Electronic Health Record.
Link: https://doi.org/10.1213/ANE.0000000000006175 Authors: Kahn, Ronald A; Gal, Jonathan S; Hofer, Ira S; Wax, David B; Villar, Joshua I; Levin, Mathew A Abstract: Visual analytics is the science of analytical reasoning supported by interactive visual interfaces called dashboards. In this report, we describe our experience addressing the challenges in visual analytics of anesthesia electronic health record…
Read MoreGenome-first recall of healthy individuals by polygenic risk score reveals differences in coronary artery calcium.
Link: https://doi.org/S0002-8703(22)00081-3 Authors: Forrest, Iain S; Chan, Lili; Chaudhary, Kumardeep; Saha, Aparna; Wen, Huei Hsun; Cepin, Cristina Liriano; Marquez-Luna, Carla; Rocheleau, Ghislain; Cho, Judy; Narula, Jagat; Nadkarni, Girish N; Do, Ron Abstract: Genetic risk for coronary artery disease (CAD) is commonly measured with polygenic risk scores (PRS); yet, the relationship of atherosclerotic burden with PRS…
Read MoreIncidence, prevalence and mortality of chronic periaortitis: a population-based study.
Link: https://doi.org/10.55563/clinexprheumatol/0v8l4j Authors: Koster, Matthew J; Ghaffar, Umar; Duong, Stephanie Q; Crowson, Cynthia S; Burke, Michelle M; Viers, Boyd R; Potretzke, Aaron M; Bjarnason, Haraldur; Warrington, Kenneth J Abstract: To evaluate the epidemiology, presentation and outcomes of patients with chronic periaortitis from 1998 through 2018. An inception cohort of patients with incident chronic periaortitis from…
Read MoreThe power of genetic diversity in genome-wide association studies of lipids.
Link: https://doi.org/10.1038/s41586-021-04064-3 Authors: Graham, Sarah E; Clarke, Shoa L; Wu, Kuan-Han H; Kanoni, Stavroula; Zajac, Greg J M; Ramdas, Shweta; Surakka, Ida; Ntalla, Ioanna; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Hwang, Mi Yeong; Han, Sohee; Narita, Akira; Choudhury, Ananyo; Bentley, Amy R; Ekoru, Kenneth; Verma, Anurag; Trivedi, Bhavi; Martin, Hilary C;…
Read MoreIdentification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants.
Link: https://doi.org/S0002-9297(21)00384-0 Authors: Sevim Bayrak, Cigdem; Stein, David; Jain, Aayushee; Chaudhary, Kumardeep; Nadkarni, Girish N; Van Vleck, Tielman T; Puel, Anne; Boisson-Dupuis, Stephanie; Okada, Satoshi; Stenson, Peter D; Cooper, David N; Schlessinger, Avner; Itan, Yuval Abstract: Identifying whether a given genetic mutation results in a gene product with increased (gain-of-function; GOF) or diminished (loss-of-function; LOF)…
Read MorePhe2vec: Automated disease phenotyping based on unsupervised embeddings from electronic health records.
Link: https://doi.org/10.1016/j.patter.2021.100337 Authors: De Freitas, Jessica K; Johnson, Kipp W; Golden, Eddye; Nadkarni, Girish N; Dudley, Joel T; Bottinger, Erwin P; Glicksberg, Benjamin S; Miotto, Riccardo Abstract: Robust phenotyping of patients from electronic health records (EHRs) at scale is a challenge in clinical informatics. Here, we introduce Phe2vec, an automated framework for disease phenotyping from…
Read MoreDownregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Link: https://doi.org/10.1038/s41467-021-24981-1 Authors: Beckmann, Noam D; Comella, Phillip H; Cheng, Esther; Lepow, Lauren; Beckmann, Aviva G; Tyler, Scott R; Mouskas, Konstantinos; Simons, Nicole W; Hoffman, Gabriel E; Francoeur, Nancy J; Del Valle, Diane Marie; Kang, Gurpawan; Do, Anh; Moya, Emily; Wilkins, Lillian; Le Berichel, Jessica; Chang, Christie; Marvin, Robert; Calorossi, Sharlene; Lansky, Alona; Walker, Laura;…
Read MoreMapping the human genetic architecture of COVID-19.
Link: https://doi.org/10.1038/s41586-021-03767-x Authors: , Abstract:
Read MoreGenetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study.
Link: https://doi.org/10.1161/CIRCULATIONAHA.120.052604 Authors: Georgakis, Marios K; Malik, Rainer; Li, Xue; Gill, Dipender; Levin, Michael G; Vy, Ha My T; Judy, Renae; Ritchie, Marylyn; Verma, Shefali S; , ; Nadkarni, Girish N; Damrauer, Scott M; Theodoratou, Evropi; Dichgans, Martin Abstract:
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