Posts Tagged ‘Nephrology’
Postoperative Acute Kidney Injury is Associated with Persistent Renal Dysfunction: A Multicenter Propensity Matched Cohort Study.
Link: https://doi.org/10.1101/2024.06.06.24308455 Authors: Stannard, Blaine; Epstein, Richard H; Gabel, Eilon; Nadkarni, Girish N; Ouyang, Yuxia; Lin, Hung-Mo; Salari, Valiollah; Hofer, Ira S Abstract: The risk of developing a persistent reduction in renal function after postoperative acute kidney injury (pAKI) is not well-established. Perform a multi-center retrospective propensity matched study evaluating whether patients that develop pAKI…
Read MoreMachine learning derived serum creatinine trajectories in acute kidney injury in critically ill patients with sepsis.
Link: https://doi.org/10.1186/s13054-024-04935-x Authors: Takkavatakarn, Kullaya; Oh, Wonsuk; Chan, Lili; Hofer, Ira; Shawwa, Khaled; Kraft, Monica; Shah, Neomi; Kohli-Seth, Roopa; Nadkarni, Girish N; Sakhuja, Ankit Abstract: Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal evaluation of this…
Read MoreLongitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD.
Link: https://doi.org/10.2215/CJN.0000000000000463 Authors: Lee, Arthur M; Xu, Yunwen; Hu, Jian; Xiao, Rui; Hooper, Stephen R; Hartung, Erum A; Coresh, Josef; Rhee, Eugene P; Vasan, Ramachandran S; Kimmel, Paul L; Warady, Bradley A; Furth, Susan L; Denburg, Michelle R; , Abstract: Longitudinal untargeted metabolomics. Children with CKD have a circulating metabolome that changes over time. Understanding…
Read MoreA clustering approach to improve our understanding of the genetic and phenotypic complexity of chronic kidney disease.
Link: https://doi.org/10.1038/s41598-024-59747-4 Authors: Eoli, A; Ibing, S; Schurmann, C; Nadkarni, G N; Heyne, H O; Böttinger, E Abstract: Chronic kidney disease (CKD) is a complex disorder that causes a gradual loss of kidney function, affecting approximately 9.1% of the world’s population. Here, we use a soft-clustering algorithm to deconstruct its genetic heterogeneity. First, we selected…
Read MoreAssociation of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression.
Link: https://doi.org/10.1681/ASN.0000000000000343 Authors: Schlosser, Pascal; Surapaneni, Aditya L; Borisov, Oleg; Schmidt, Insa M; Zhou, Linda; Anderson, Amanda; Deo, Rajat; Dubin, Ruth; Ganz, Peter; He, Jiang; Kimmel, Paul L; Li, Hongzhe; Nelson, Robert G; Porter, Anna C; Rahman, Mahboob; Rincon-Choles, Hernan; Shah, Vallabh; Unruh, Mark L; Vasan, Ramachandran S; Zheng, Zihe; Feldman, Harold I; Waikar, Sushrut…
Read MoreIntegrated multiomics implicates dysregulation of ECM and cell adhesion pathways as drivers of severe COVID-associated kidney injury.
Link: https://doi.org/10.1101/2024.03.18.24304401 Authors: Anandakrishnan, Nanditha; Yi, Zhengzi; Sun, Zeguo; Liu, Tong; Haydak, Jonathan; Eddy, Sean; Jayaraman, Pushkala; DeFronzo, Stefanie; Saha, Aparna; Sun, Qian; Yang, Dai; Mendoza, Anthony; Mosoyan, Gohar; Wen, Huei Hsun; Schaub, Jennifer A; Fu, Jia; Kehrer, Thomas; Menon, Rajasree; Otto, Edgar A; Godfrey, Bradley; Suarez-Farinas, Mayte; Leffters, Sean; Twumasi, Akosua; Meliambro, Kristin; Charney,…
Read MoreMachine learning models to predict end-stage kidney disease in chronic kidney disease stage 4.
Link: https://doi.org/10.1186/s12882-023-03424-7 Authors: Takkavatakarn, Kullaya; Oh, Wonsuk; Cheng, Ella; Nadkarni, Girish N; Chan, Lili Abstract: End-stage kidney disease (ESKD) is associated with increased morbidity and mortality. Identifying patients with stage 4 CKD (CKD4) at risk of rapid progression to ESKD remains challenging. Accurate prediction of CKD4 progression can improve patient outcomes by improving advanced care…
Read MoreGenome-Wide Polygenic Risk Score for CKD in Individuals with APOL1 High-Risk Genotypes.
Link: https://doi.org/10.2215/CJN.0000000000000379 Authors: Vy, Ha My T; Coca, Steven G; Sawant, Ashwin; Sakhuja, Ankit; Gutierrez, Orlando M; Cooper, Richard; Loos, Ruth J F; Horowitz, Carol R; Do, Ron; Nadkarni, Girish N Abstract:
Read MorePeripheral Transcriptomics in Acute and Long-Term Kidney Dysfunction in SARS-CoV2 Infection.
Link: https://doi.org/10.1101/2023.10.25.23297469 Authors: Jayaraman, Pushkala; Rajagopal, Madhumitha; Paranjpe, Ishan; Liharska, Lora; Suarez-Farinas, Mayte; Thompson, Ryan; Del Valle, Diane Marie; Beckmann, Noam; Oh, Wonsuk; Gulamali, Faris F; Kauffman, Justin; Gonzalez-Kozlova, Edgar; Dellepiane, Sergio; Vasquez-Rios, George; Vaid, Akhil; Jiang, Joy; Chen, Annie; Sakhuja, Ankit; Chen, Steven; Kenigsberg, Ephraim; He, John Cijiang; Coca, Steven G; Chan, Lili; Schadt,…
Read MoreCirculating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD.
Link: https://doi.org/10.2215/CJN.0000000000000318 Authors: Lee, Arthur M; Xu, Yunwen; Hooper, Stephen R; Abraham, Alison G; Hu, Jian; Xiao, Rui; Matheson, Matthew B; Brunson, Celina; Rhee, Eugene P; Coresh, Josef; Vasan, Ramachandran S; Schrauben, Sarah; Kimmel, Paul L; Warady, Bradley A; Furth, Susan L; Hartung, Erum A; Denburg, Michelle R; , Abstract: Children with CKD are at…
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