Posts Tagged ‘Nephrology’
Applications of machine learning methods in kidney disease: hope or hype?
Link: https://doi.org/10.1097/MNH.0000000000000604 Authors: Chan, Lili; Vaid, Akhil; Nadkarni, Girish N Abstract: The universal adoption of electronic health records, improvement in technology, and the availability of continuous monitoring has generated large quantities of healthcare data. Machine learning is increasingly adopted by nephrology researchers to analyze this data in order to improve the care of their patients.…
Read MoreNatural Language Processing in Nephrology.
Link: https://doi.org/S1548-5595(22)00128-8 Authors: Van Vleck, Tielman T; Farrell, Douglas; Chan, Lili Abstract: Unstructured data in the electronic health records contain essential patient information. Natural language processing (NLP), teaching a computer to read, allows us to tap into these data without needing the time and effort of manual chart abstraction. The core first step for all…
Read MoreReal World Evidence and Clinical Utility of KidneyIntelX on Patients With Early-Stage Diabetic Kidney Disease: Interim Results on Decision Impact and Outcomes.
Link: https://doi.org/10.1177/21501319221138196 Authors: Tokita, Joji; Vega, Aida; Sinfield, Catherine; Naik, Nidhi; Rathi, Shivani; Martin, Sharlene; Wang, Stephanie; Amoruso, Leonard; Zabetian, Azadeh; Coca, Steven G; Nadkarni, Girish N; Fleming, Fergus; Donovan, Michael J; Fields, Robert Abstract: The lack of precision to identify patients with early-stage diabetic kidney disease (DKD) at near-term risk for progressive decline in…
Read MoreLumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
Link: https://doi.org/10.1056/NEJMoa2021712 Authors: Garrelfs, Sander F; Frishberg, Yaacov; Hulton, Sally A; Koren, Michael J; O’Riordan, William D; Cochat, Pierre; Deschênes, Georges; Shasha-Lavsky, Hadas; Saland, Jeffrey M; Van’t Hoff, William G; Fuster, Daniel G; Magen, Daniella; Moochhala, Shabbir H; Schalk, Gesa; Simkova, Eva; Groothoff, Jaap W; Sas, David J; Meliambro, Kristin A; Lu, Jiandong; Sweetser, Marianne…
Read MoreA Real-World Precision Medicine Program Including the KidneyIntelX Test Effectively Changes Management Decisions and Outcomes for Patients With Early-Stage Diabetic Kidney Disease.
Link: https://doi.org/10.1177/21501319231223437 Authors: Tokita, Joji; Lam, David; Vega, Aida; Wang, Stephanie; Amoruso, Leonard; Muller, Tamara; Naik, Nidhi; Rathi, Shivani; Martin, Sharlene; Zabetian, Azadeh; Liu, Catherine; Sinfield, Catherine; McNicholas, Tony; Fleming, Fergus; Coca, Steven G; Nadkarni, Girish N; Tun, Roger; Kattan, Mike; Donovan, Michael J; Rahim, Arshad K Abstract: The KidneyIntelX is a multiplex, bioprognostic, immunoassay…
Read MoreMetabolite Biomarkers of CKD Progression in Children.
Link: https://doi.org/10.2215/CJN.00220121 Authors: Denburg, Michelle R; Xu, Yunwen; Abraham, Alison G; Coresh, Josef; Chen, Jingsha; Grams, Morgan E; Feldman, Harold I; Kimmel, Paul L; Rebholz, Casey M; Rhee, Eugene P; Vasan, Ramachandran S; Warady, Bradley A; Furth, Susan L; , Abstract: Metabolomics facilitates the discovery of biomarkers and potential therapeutic targets for CKD progression. We…
Read MoreAnalysis of Biomarkers Within the Initial 2 Years Posttransplant and 5-Year Kidney Transplant Outcomes: Results From Clinical Trials in Organ Transplantation-17.
Link: https://doi.org/10.1097/TP.0000000000002026 Authors: Faddoul, Geovani; Nadkarni, Girish N; Bridges, Nancy D; Goebel, Jens; Hricik, Donald E; Formica, Richard; Menon, Madhav C; Morrison, Yvonne; Murphy, Barbara; Newell, Kenneth; Nickerson, Peter; Poggio, Emilio D; Rush, David; Heeger, Peter S; , Abstract: An early posttransplant biomarker/surrogate marker for kidney allograft loss has the potential to guide targeted interventions.…
Read MoreTrends of Acute Kidney Injury Requiring Dialysis Among Hospitalized Patients Undergoing Invasive Electrophysiology Procedures.
Link: https://doi.org/10.1097/HPC.0000000000000214 Authors: Wen, Yumeng; Hosseini Dehkordi, Seyed Hamed; Wei, Xin; Lucas, Claire Huang; Paranjpe, Ishan; Yan, Dexi; Gholitabar, Farid; Mehta, Davendra; Chan, Lili; Meisels, Ira Abstract: Electrophysiology (EP) procedures carry the risk of kidney injury due to contrast/hemodynamic fluctuations. We aim to evaluate the national epidemiology of acute kidney injury requiring dialysis (AKI-D) in…
Read MoreSerum potassium and adverse outcomes across the range of kidney function: a CKD Prognosis Consortium meta-analysis.
Link: https://doi.org/10.1093/eurheartj/ehy100 Authors: Kovesdy, Csaba P; Matsushita, Kunihiro; Sang, Yingying; Brunskill, Nigel J; Carrero, Juan J; Chodick, Gabriel; Hasegawa, Takeshi; Heerspink, Hiddo L; Hirayama, Atsushi; Landman, Gijs W D; Levin, Adeera; Nitsch, Dorothea; Wheeler, David C; Coresh, Josef; Hallan, Stein I; Shalev, Varda; Grams, Morgan E; , Abstract: Both hypo- and hyperkalaemia can have immediate…
Read MoreType 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts.
Link: https://doi.org/10.2337/dc21-1395 Authors: DiCorpo, Daniel; LeClair, Jessica; Cole, Joanne B; Sarnowski, Chloé; Ahmadizar, Fariba; Bielak, Lawrence F; Blokstra, Anneke; Bottinger, Erwin P; Chaker, Layal; Chen, Yii-Der I; Chen, Ye; de Vries, Paul S; Faquih, Tariq; Ghanbari, Mohsen; Gudmundsdottir, Valborg; Guo, Xiuqing; Hasbani, Natalie R; Ibi, Dorina; Ikram, M Arfan; Kavousi, Maryam; Leonard, Hampton L; Leong,…
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