Real World Evidence and Clinical Utility of KidneyIntelX on Patients With Early-Stage Diabetic Kidney Disease: Interim Results on Decision Impact and Outcomes.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1177/21501319221138196 Authors: Tokita, Joji; Vega, Aida; Sinfield, Catherine; Naik, Nidhi; Rathi, Shivani; Martin, Sharlene; Wang, Stephanie; Amoruso, Leonard; Zabetian, Azadeh; Coca, Steven G; Nadkarni, Girish N; Fleming, Fergus; Donovan, Michael J; Fields, Robert Abstract: The lack of precision to identify patients with early-stage diabetic kidney disease (DKD) at near-term risk for progressive decline in…

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A Real-World Precision Medicine Program Including the KidneyIntelX Test Effectively Changes Management Decisions and Outcomes for Patients With Early-Stage Diabetic Kidney Disease.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1177/21501319231223437 Authors: Tokita, Joji; Lam, David; Vega, Aida; Wang, Stephanie; Amoruso, Leonard; Muller, Tamara; Naik, Nidhi; Rathi, Shivani; Martin, Sharlene; Zabetian, Azadeh; Liu, Catherine; Sinfield, Catherine; McNicholas, Tony; Fleming, Fergus; Coca, Steven G; Nadkarni, Girish N; Tun, Roger; Kattan, Mike; Donovan, Michael J; Rahim, Arshad K Abstract: The KidneyIntelX is a multiplex, bioprognostic, immunoassay…

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Development and Validation of Prediction Models of Adverse Kidney Outcomes in the Population With and Without Diabetes.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.2337/dc22-0698 Authors: Grams, Morgan E; Brunskill, Nigel J; Ballew, Shoshana H; Sang, Yingying; Coresh, Josef; Matsushita, Kunihiro; Surapaneni, Aditya; Bell, Samira; Carrero, Juan J; Chodick, Gabriel; Evans, Marie; Heerspink, Hiddo J L; Inker, Lesley A; Iseki, Kunitoshi; Kalra, Philip A; Kirchner, H Lester; Lee, Brian J; Levin, Adeera; Major, Rupert W; Medcalf, James; Nadkarni,…

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Metabolite Biomarkers of CKD Progression in Children.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.2215/CJN.00220121 Authors: Denburg, Michelle R; Xu, Yunwen; Abraham, Alison G; Coresh, Josef; Chen, Jingsha; Grams, Morgan E; Feldman, Harold I; Kimmel, Paul L; Rebholz, Casey M; Rhee, Eugene P; Vasan, Ramachandran S; Warady, Bradley A; Furth, Susan L; , Abstract: Metabolomics facilitates the discovery of biomarkers and potential therapeutic targets for CKD progression. We…

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Continuous Kidney Replacement Therapy of the Future: Innovations in Information Technology, Data Analytics, and Quality Assurance Systems.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S1548-5595(21)00031-8 Authors: Neyra, Javier A; Nadkarni, Girish N Abstract: Continuous kidney replacement therapy is commonly used in the critically ill population. Despite the recent development in continuous kidney replacement therapy technology and clinical informatics, many aspects of continuous kidney replacement therapy delivery are still not fully standardized, and quality assurance programs for the provision…

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Natural Language Processing in Nephrology.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S1548-5595(22)00128-8 Authors: Van Vleck, Tielman T; Farrell, Douglas; Chan, Lili Abstract: Unstructured data in the electronic health records contain essential patient information. Natural language processing (NLP), teaching a computer to read, allows us to tap into these data without needing the time and effort of manual chart abstraction. The core first step for all…

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Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1056/NEJMoa2021712 Authors: Garrelfs, Sander F; Frishberg, Yaacov; Hulton, Sally A; Koren, Michael J; O’Riordan, William D; Cochat, Pierre; Deschênes, Georges; Shasha-Lavsky, Hadas; Saland, Jeffrey M; Van’t Hoff, William G; Fuster, Daniel G; Magen, Daniella; Moochhala, Shabbir H; Schalk, Gesa; Simkova, Eva; Groothoff, Jaap W; Sas, David J; Meliambro, Kristin A; Lu, Jiandong; Sweetser, Marianne…

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