Artificial intelligence-enabled decision support in nephrology.

Link: https://doi.org/10.1038/s41581-022-00562-3 Authors: Loftus, Tyler J; Shickel, Benjamin; Ozrazgat-Baslanti, Tezcan; Ren, Yuanfang; Glicksberg, Benjamin S; Cao, Jie; Singh, Karandeep; Chan, Lili; Nadkarni, Girish N; Bihorac, Azra Abstract: Kidney pathophysiology is often complex, nonlinear and heterogeneous, which limits the utility of hypothetical-deductive reasoning and linear, statistical approaches to diagnosis and treatment. Emerging evidence suggests that artificial…

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Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease.

Link: https://doi.org/S0272-6386(22)00577-7 Authors: Sapa, Hima; Gutiérrez, Orlando M; Shlipak, Michael G; Katz, Ronit; Ix, Joachim H; Sarnak, Mark J; Cushman, Mary; Rhee, Eugene P; Kimmel, Paul L; Vasan, Ramachandran S; Schrauben, Sarah J; Feldman, Harold I; Seegmiller, Jesse C; Brunengraber, Henri; Hostetter, Thomas H; Schelling, Jeffrey R; , Abstract: Cardiovascular disease (CVD) is a major…

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Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D.

Link: https://doi.org/10.1681/ASN.2021060735 Authors: Chen, Teresa K; Coca, Steven G; Estrella, Michelle M; Appel, Lawrence J; Coresh, Josef; Thiessen Philbrook, Heather; Obeid, Wassim; Fried, Linda F; Heerspink, Hiddo J L; Ix, Joachim H; Shlipak, Michael G; Kimmel, Paul L; Parikh, Chirag R; Grams, Morgan E; , Abstract: Higher baseline levels of soluble TNF receptors (TNFR1 and…

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Electroencephalography at the height of a pandemic: EEG findings in patients with COVID-19.

Link: https://doi.org/S1388-2457(22)00190-0 Authors: Tantillo, Gabriela B; Jetté, Nathalie; Gururangan, Kapil; Agarwal, Parul; Marcuse, Lara; Singh, Anuradha; Goldstein, Jonathan; Kwon, Churl-Su; Dhamoon, Mandip S; Navis, Allison; Nadkarni, Girish N; Charney, Alexander W; Young, James J; Blank, Leah J; Fields, Madeline; Yoo, Ji Yeoun Abstract: To characterize continuous video electroencephalogram (VEEG) findings of hospitalized COVID-19 patients. We…

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Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial.

Link: https://doi.org/10.1001/jamanetworkopen.2022.1048 Authors: Nadkarni, Girish N; Fei, Kezhen; Ramos, Michelle A; Hauser, Diane; Bagiella, Emilia; Ellis, Stephen B; Sanderson, Saskia; Scott, Stuart A; Sabin, Tatiana; Madden, Ebony; Cooper, Richard; Pollak, Martin; Calman, Neil; Bottinger, Erwin P; Horowitz, Carol R Abstract: Risk variants in the apolipoprotein L1 (APOL1 [OMIM 603743]) gene on chromosome 22 are common…

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Post-operative Morbidity and Mortality After Fontan Procedure in Patients with Heterotaxy and Other Situs Anomalies.

Link: https://doi.org/10.1007/s00246-021-02804-w Authors: Duong, Son Q; Zaniletti, Isabella; Lopez, Leo; Sutherland, Scott M; Shin, Andrew Y; Collins, R Thomas Abstract: Heterotaxy is a complex, multisystem disorder associated with single ventricle heart disease and decreased survival. Ciliary dysfunction is common in heterotaxy and other situs abnormalities (H/SA) and may increase post-operative complications. We hypothesized that patients…

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Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial.

Link: https://doi.org/10.1159/000519920 Authors: Lam, David; Nadkarni, Girish N; Mosoyan, Gohar; Neal, Bruce; Mahaffey, Kenneth W; Rosenthal, Norman; Hansen, Michael K; Heerspink, Hiddo J L; Fleming, Fergus; Coca, Steven G Abstract: KidneyIntelX is a composite risk score, incorporating biomarkers and clinical variables for predicting progression of diabetic kidney disease (DKD). The utility of this score in…

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Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19.

Link: https://doi.org/10.1159/000520355 Authors: Chauhan, Kinsuk; Pattharanitima, Pattharawin; Piani, Federica; Johnson, Richard J; Uribarri, Jaime; Chan, Lili; Coca, Steven G Abstract: Coronavirus 2019 (COVID-19) can increase catabolism and result in hyperuricemia. Uric acid (UA) potentially causes kidney damage by alteration of renal autoregulation, inhibition of endothelial cell proliferation, cell apoptosis, activation of the pro-inflammatory cascade, and…

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