Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19.

Link: https://doi.org/10.1161/CIRCOUTCOMES.122.008942 Authors: Vasbinder, Alexi; Meloche, Chelsea; Azam, Tariq U; Anderson, Elizabeth; Catalan, Tonimarie; Shadid, Husam; Berlin, Hanna; Pan, Michael; O’Hayer, Patrick; Padalia, Kishan; Blakely, Pennelope; Khaleel, Ibrahim; Michaud, Erinleigh; Huang, Yiyuan; Zhao, Lili; Pop-Busui, Rodica; Gupta, Shruti; Eagle, Kim; Leaf, David E; Hayek, Salim S; , Abstract: Preexisting cardiovascular disease (CVD) is perceived as…

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Allostatic load predicts racial disparities in intracerebral hemorrhage cognitive outcomes.

Link: https://doi.org/10.1038/s41598-022-20987-x Authors: Harris, Jennifer; Boehme, Amelia; Chan, Luisa; Moats, Harmon; Dugue, Rachelle; Izeogu, Chigozirim; Pavol, Marykay A; Naqvi, Imama A; Williams, Olajide; Marshall, Randolph S Abstract: A large portion of stroke disparities remains unexplained, even after adjusting for demographic, comorbidity, and health care access variables. There is a critical need to close this knowledge…

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The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.

Link: https://doi.org/10.1186/s12014-022-09371-z Authors: Butler-Laporte, Guillaume; Gonzalez-Kozlova, Edgar; Su, Chen-Yang; Zhou, Sirui; Nakanishi, Tomoko; Brunet-Ratnasingham, Elsa; Morrison, David; Laurent, Laetitia; Afilalo, Jonathan; Afilalo, Marc; Henry, Danielle; Chen, Yiheng; Carrasco-Zanini, Julia; Farjoun, Yossi; Pietzner, Maik; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Bouab, Meriem; Petitjean, Louis; Guzman, Charlotte; Xue, Xiaoqing; Tselios, Chris; Vulesevic, Branka; Adeleye, Olumide; Abdullah, Tala;…

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Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.

Link: https://doi.org/10.1161/CIRCULATIONAHA.122.059675 Authors: Thibord, Florian; Klarin, Derek; Brody, Jennifer A; Chen, Ming-Huei; Levin, Michael G; Chasman, Daniel I; Goode, Ellen L; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L; Nadkarni, Girish N; de Vries, Paul S; Cuellar-Partida, Gabriel; Wolford, Brooke N; Pattee, Jack W; Kooperberg, Charles;…

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Visual Analytics to Leverage Anesthesia Electronic Health Record.

Link: https://doi.org/10.1213/ANE.0000000000006175 Authors: Kahn, Ronald A; Gal, Jonathan S; Hofer, Ira S; Wax, David B; Villar, Joshua I; Levin, Mathew A Abstract: Visual analytics is the science of analytical reasoning supported by interactive visual interfaces called dashboards. In this report, we describe our experience addressing the challenges in visual analytics of anesthesia electronic health record…

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Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.

Link: https://doi.org/10.7554/eLife.78163 Authors: Cai, Wesley L; Chen, Jocelyn Fang-Yi; Chen, Huacui; Wingrove, Emily; Kurley, Sarah J; Chan, Lok Hei; Zhang, Meiling; Arnal-Estape, Anna; Zhao, Minghui; Balabaki, Amer; Li, Wenxue; Yu, Xufen; Krop, Ethan D; Dou, Yali; Liu, Yansheng; Jin, Jian; Westbrook, Thomas F; Nguyen, Don X; Yan, Qin Abstract: Metastatic breast cancer remains a major…

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Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.

Link: https://doi.org/10.1097/CCE.0000000000000755 Authors: Sunderraj, Ashwin; Cho, Chloe; Cai, Xuan; Gupta, Shruti; Mehta, Rupal; Isakova, Tamara; Leaf, David E; Srivastava, Anand; , Abstract: Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between…

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Proteomic Characterization of Acute Kidney Injury in Patients Hospitalized with SARS-CoV2 Infection.

Link: https://doi.org/10.1101/2021.12.09.21267548 Authors: Paranjpe, Ishan; Jayaraman, Pushkala; Su, Chen-Yang; Zhou, Sirui; Chen, Steven; Thompson, Ryan; Del Valle, Diane Marie; Kenigsberg, Ephraim; Zhao, Shan; Jaladanki, Suraj; Chaudhary, Kumardeep; Ascolillo, Steven; Vaid, Akhil; Kumar, Arvind; Kozlova, Edgar; Paranjpe, Manish; O’Hagan, Ross; Kamat, Samir; Gulamali, Faris F; Kauffman, Justin; Xie, Hui; Harris, Joceyln; Patel, Manishkumar; Argueta, Kimberly; Batchelor,…

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