Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.

Link: https://doi.org/10.1038/s41467-022-34216-6 Authors: Levin, Michael G; Tsao, Noah L; Singhal, Pankhuri; Liu, Chang; Vy, Ha My T; Paranjpe, Ishan; Backman, Joshua D; Bellomo, Tiffany R; Bone, William P; Biddinger, Kiran J; Hui, Qin; Dikilitas, Ozan; Satterfield, Benjamin A; Yang, Yifan; Morley, Michael P; Bradford, Yuki; Burke, Megan; Reza, Nosheen; Charest, Brian; , ; Judy, Renae…

Read More

Epidemiology of Cutaneous Lupus Erythematosus Among Adults Over Four Decades (1976-2018): A Lupus Midwest Network (LUMEN) Study.

Link: https://doi.org/S0025-6196(22)00379-2 Authors: Hocaoğlu, Mehmet; Davis, Mark Denis P; Osei-Onomah, Shirley-Ann; Valenzuela-Almada, Maria O; Dabit, Jesse Y; Duong, Stephanie Q; Yang, Jeffrey X; Helmick, Charles G; Crowson, Cynthia; Duarte-García, Alí Abstract: To characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota. In this retrospective population-based…

Read More

Unplanned 30-Day Readmission Rates for Autosomal Dominant Polycystic Kidney Disease: Insight from the Nationwide Readmissions Database.

Link: https://doi.org/10.1159/000526923 Authors: Saha, Aparna; Ericksen, Paulette; Liriano Cepin, Cristina; Nadkarni, Girish N; Chan, Lili Abstract: Among end-stage kidney disease (ESKD) patients on dialysis with autosomal dominant polycystic kidney disease (ADPKD), relatively little is known about the epidemiology and risk factors for 30-day readmissions in the USA. Therefore, we evaluated the 30-day unplanned readmission rates…

Read More

Criteria for Early Pacemaker Implantation in Patients With Postoperative Heart Block After Congenital Heart Surgery.

Link: https://doi.org/10.1161/CIRCEP.122.011145 Authors: Duong, Son Q; Shi, Yuan; Giacone, Heather; Navarre, Brittany M; Gal, Dana B; Han, Brian; Sganga, Danielle; Ma, Michael; Reddy, Charitha D; Shin, Andrew Y; Kwiatkowski, David M; Dubin, Anne M; Scheinker, David; Algaze, Claudia A Abstract: Guidelines recommend observation for atrioventricular node recovery until postoperative days (POD) 7 to 10 before…

Read More

Laboratory Result Reference Ranges Stratified for Patient-Reported Sex and Ethnicity Are More Closely Associated With Postoperative Outcomes Than Currently Used Reference Ranges: A Retrospective Data Analysis.

Link: https://doi.org/10.1213/ANE.0000000000006229 Authors: Hofer, Ira S; Lee, Andrew; Grogan, Tristan; Lucero, Jennifer; Cannesson, Maxime Abstract: A single laboratory range for all individuals may fail to take into account underlying physiologic differences based on sex and genetic factors. We hypothesized that laboratory distributions differ based on self-reported sex and ethnicity and that ranges stratified by these…

Read More

Mendelian gene identification through mouse embryo viability screening.

Link: https://doi.org/10.1186/s13073-022-01118-7 Authors: Cacheiro, Pilar; Westerberg, Carl Henrik; Mager, Jesse; Dickinson, Mary E; Nutter, Lauryl M J; Muñoz-Fuentes, Violeta; Hsu, Chih-Wei; Van den Veyver, Ignatia B; Flenniken, Ann M; McKerlie, Colin; Murray, Stephen A; Teboul, Lydia; Heaney, Jason D; Lloyd, K C Kent; Lanoue, Louise; Braun, Robert E; White, Jacqueline K; Creighton, Amie K; Laurin,…

Read More

Survival After Out-of-Hospital Cardiac Arrest: The Role of Racial Residential Segregation.

Link: https://doi.org/10.1007/s11524-022-00691-x Authors: Abbott, Ethan E; Buckler, David G; Hsu, Jesse Y; Jacoby, Sara F; Abella, Benjamin S; Richardson, Lynne D; Carr, Brendan G; Zebrowski, Alexis M Abstract: Racial and racialized economic residential segregation has been empirically associated with outcomes across multiple health conditions but not yet explored in relation to out-of-hospital cardiac arrest (OHCA).…

Read More

Higher Symptom Frequency and Severity After the Long Interdialytic Interval in Patients on Maintenance Intermittent Hemodialysis.

Link: https://doi.org/10.1016/j.ekir.2022.09.032 Authors: Chauhan, Kinsuk; Wen, Huei Hsun; Gupta, Neepa; Nadkarni, Girish; Coca, Steven; Chan, Lili Abstract: Patients on intermittent hemodialysis (HD) have a high symptom burden. Though studies report higher hospitalizations and mortality after the long interdialytic interval, whether symptoms vary based on the interdialytic interval is unclear. This is a prospective observational study…

Read More