Posts by Amir Safavi
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
Link: https://doi.org/S0085-2538(22)00454-9 Authors: Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent F; Graham, Sarah E; Sveinbjornsson, Gardar; Winkler, Thomas W; Günther, Felix; Stark, Klaus J; Chai, Jin-Fang; Tayo, Bamidele O; Wuttke, Matthias; Li, Yong; Tin, Adrienne; Ahluwalia, Tarunveer S; Ärnlöv, Johan; Åsvold, Bjørn Olav; Bakker, Stephan J L; Banas, Bernhard; Bansal, Nisha; Biggs, Mary L;…
Read MoreDifferential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
Link: https://doi.org/10.1038/s42003-022-03448-z Authors: Winkler, Thomas W; Rasheed, Humaira; Teumer, Alexander; Gorski, Mathias; Rowan, Bryce X; Stanzick, Kira J; Thomas, Laurent F; Tin, Adrienne; Hoppmann, Anselm; Chu, Audrey Y; Tayo, Bamidele; Thio, Chris H L; Cusi, Daniele; Chai, Jin-Fang; Sieber, Karsten B; Horn, Katrin; Li, Man; Scholz, Markus; Cocca, Massimiliano; Wuttke, Matthias; van der Most, Peter…
Read MoreThe promise of artificial intelligence for kidney pathophysiology.
Link: https://doi.org/10.1097/MNH.0000000000000808 Authors: Jiang, Joy; Chan, Lili; Nadkarni, Girish N Abstract: We seek to determine recent advances in kidney pathophysiology that have been enabled or enhanced by artificial intelligence. We describe some of the challenges in the field as well as future directions. We first provide an overview of artificial intelligence terminologies and methodologies. We…
Read MoreAutomated Determination of Left Ventricular Function Using Electrocardiogram Data in Patients on Maintenance Hemodialysis.
Link: https://doi.org/10.2215/CJN.16481221 Authors: Vaid, Akhil; Jiang, Joy J; Sawant, Ashwin; Singh, Karandeep; Kovatch, Patricia; Charney, Alexander W; Charytan, David M; Divers, Jasmin; Glicksberg, Benjamin S; Chan, Lili; Nadkarni, Girish N Abstract: Left ventricular ejection fraction is disrupted in patients on maintenance hemodialysis and can be estimated using deep learning models on electrocardiograms. Smaller sample sizes…
Read MoreInsights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.
Link: https://doi.org/10.1161/HYPERTENSIONAHA.122.19324 Authors: Kelly, Tanika N; Sun, Xiao; He, Karen Y; Brown, Michael R; Taliun, Sarah A Gagliano; Hellwege, Jacklyn N; Irvin, Marguerite R; Mi, Xuenan; Brody, Jennifer A; Franceschini, Nora; Guo, Xiuqing; Hwang, Shih-Jen; de Vries, Paul S; Gao, Yan; Moscati, Arden; Nadkarni, Girish N; Yanek, Lisa R; Elfassy, Tali; Smith, Jennifer A; Chung,…
Read MoreDesign and rationale of GUARDD-US: A pragmatic, randomized trial of genetic testing for APOL1 and pharmacogenomic predictors of antihypertensive efficacy in patients with hypertension.
Link: https://doi.org/S1551-7144(22)00139-2 Authors: Eadon, Michael T; Cavanaugh, Kerri L; Orlando, Lori A; Christian, David; Chakraborty, Hrishikesh; Steen-Burrell, Kady-Ann; Merrill, Peter; Seo, Janet; Hauser, Diane; Singh, Rajbir; Beasley, Cherry Maynor; Fuloria, Jyotsna; Kitzman, Heather; Parker, Alexander S; Ramos, Michelle; Ong, Henry H; Elwood, Erica N; Lynch, Sheryl E; Clermont, Sabrina; Cicali, Emily J; Starostik, Petr; Pratt,…
Read MoreModular Fluted Tapered Stems for Periprosthetic Femoral Fractures: Excellent Results in 171 Cases.
Link: https://doi.org/10.2106/JBJS.21.01168 Authors: Hannon, Charles P; Sheehan, Kevin P; Duong, Stephanie Q; Yuan, Brandon J; Lewallen, David G; Berry, Daniel J; Abdel, Matthew P Abstract: Modular fluted tapered (MFT) stems have advanced treatment of Vancouver B2 and B3 periprosthetic femoral fractures, but series to date have been limited with respect to cohort size and follow-up…
Read MoreProteomic Analyses Unveil Actionable Disease Pathways in COVID-19: A Step Toward Targeted Therapies.
Link: https://doi.org/10.1016/j.jacbts.2022.03.011 Authors: Vasquez-Rios, George; Nadkarni, Girish N Abstract:
Read MoreEvaluation of a machine learning approach utilizing wearable data for prediction of SARS-CoV-2 infection in healthcare workers.
Link: https://doi.org/10.1093/jamiaopen/ooac041 Authors: Hirten, Robert P; Tomalin, Lewis; Danieletto, Matteo; Golden, Eddye; Zweig, Micol; Kaur, Sparshdeep; Helmus, Drew; Biello, Anthony; Pyzik, Renata; Bottinger, Erwin P; Keefer, Laurie; Charney, Dennis; Nadkarni, Girish N; Suarez-Farinas, Mayte; Fayad, Zahi A Abstract: To determine whether a machine learning model can detect SARS-CoV-2 infection from physiological metrics collected from wearable…
Read MoreHispanic ethnicity and mortality among critically ill patients with COVID-19.
Link: https://doi.org/10.1371/journal.pone.0268022 Authors: Ricardo, Ana C; Chen, Jinsong; Toth-Manikowski, Stephanie M; Meza, Natalie; Joo, Min; Gupta, Shruti; Lazarous, Deepa G; Leaf, David E; Lash, James P; , Abstract: Hispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Whether this…
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