Posts by Amir Safavi
Rising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades.
Link: https://doi.org/10.1136/annrheumdis-2022-222276 Authors: Duarte-García, Alí; Hocaoglu, Mehmet; Valenzuela-Almada, Maria; Osei-Onomah, Shirley-Ann; Dabit, Jesse Y; Sanchez-Rodriguez, Alain; Duong, Stephanie Q; Giblon, Rachel E; Langenfeld, Hannah E; Alarcón, Graciela S; Helmick, Charles G; Crowson, Cynthia S Abstract: To determine the trends in incidence, prevalence and mortality of systemic lupus erythematosus (SLE) in a US population over four…
Read MoreMulti-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.
Link: https://doi.org/10.1038/s41588-022-01058-3 Authors: Mahajan, Anubha; Spracklen, Cassandra N; Zhang, Weihua; Ng, Maggie C Y; Petty, Lauren E; Kitajima, Hidetoshi; Yu, Grace Z; Rüeger, Sina; Speidel, Leo; Kim, Young Jin; Horikoshi, Momoko; Mercader, Josep M; Taliun, Daniel; Moon, Sanghoon; Kwak, Soo-Heon; Robertson, Neil R; Rayner, Nigel W; Loh, Marie; Kim, Bong-Jo; Chiou, Joshua; Miguel-Escalada, Irene; Della…
Read MoreGenome-first recall of healthy individuals by polygenic risk score reveals differences in coronary artery calcium.
Link: https://doi.org/S0002-8703(22)00081-3 Authors: Forrest, Iain S; Chan, Lili; Chaudhary, Kumardeep; Saha, Aparna; Wen, Huei Hsun; Cepin, Cristina Liriano; Marquez-Luna, Carla; Rocheleau, Ghislain; Cho, Judy; Narula, Jagat; Nadkarni, Girish N; Do, Ron Abstract: Genetic risk for coronary artery disease (CAD) is commonly measured with polygenic risk scores (PRS); yet, the relationship of atherosclerotic burden with PRS…
Read MoreArtificial intelligence-enabled decision support in nephrology.
Link: https://doi.org/10.1038/s41581-022-00562-3 Authors: Loftus, Tyler J; Shickel, Benjamin; Ozrazgat-Baslanti, Tezcan; Ren, Yuanfang; Glicksberg, Benjamin S; Cao, Jie; Singh, Karandeep; Chan, Lili; Nadkarni, Girish N; Bihorac, Azra Abstract: Kidney pathophysiology is often complex, nonlinear and heterogeneous, which limits the utility of hypothetical-deductive reasoning and linear, statistical approaches to diagnosis and treatment. Emerging evidence suggests that artificial…
Read MoreAssociation of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease.
Link: https://doi.org/S0272-6386(22)00577-7 Authors: Sapa, Hima; Gutiérrez, Orlando M; Shlipak, Michael G; Katz, Ronit; Ix, Joachim H; Sarnak, Mark J; Cushman, Mary; Rhee, Eugene P; Kimmel, Paul L; Vasan, Ramachandran S; Schrauben, Sarah J; Feldman, Harold I; Seegmiller, Jesse C; Brunengraber, Henri; Hostetter, Thomas H; Schelling, Jeffrey R; , Abstract: Cardiovascular disease (CVD) is a major…
Read MoreLongitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D.
Link: https://doi.org/10.1681/ASN.2021060735 Authors: Chen, Teresa K; Coca, Steven G; Estrella, Michelle M; Appel, Lawrence J; Coresh, Josef; Thiessen Philbrook, Heather; Obeid, Wassim; Fried, Linda F; Heerspink, Hiddo J L; Ix, Joachim H; Shlipak, Michael G; Kimmel, Paul L; Parikh, Chirag R; Grams, Morgan E; , Abstract: Higher baseline levels of soluble TNF receptors (TNFR1 and…
Read MoreWhole-genome sequencing reveals host factors underlying critical COVID-19.
Link: https://doi.org/10.1038/s41586-022-04576-6 Authors: Kousathanas, Athanasios; Pairo-Castineira, Erola; Rawlik, Konrad; Stuckey, Alex; Odhams, Christopher A; Walker, Susan; Russell, Clark D; Malinauskas, Tomas; Wu, Yang; Millar, Jonathan; Shen, Xia; Elliott, Katherine S; Griffiths, Fiona; Oosthuyzen, Wilna; Morrice, Kirstie; Keating, Sean; Wang, Bo; Rhodes, Daniel; Klaric, Lucija; Zechner, Marie; Parkinson, Nick; Siddiq, Afshan; Goddard, Peter; Donovan, Sally; Maslove,…
Read MoreElectroencephalography at the height of a pandemic: EEG findings in patients with COVID-19.
Link: https://doi.org/S1388-2457(22)00190-0 Authors: Tantillo, Gabriela B; Jetté, Nathalie; Gururangan, Kapil; Agarwal, Parul; Marcuse, Lara; Singh, Anuradha; Goldstein, Jonathan; Kwon, Churl-Su; Dhamoon, Mandip S; Navis, Allison; Nadkarni, Girish N; Charney, Alexander W; Young, James J; Blank, Leah J; Fields, Madeline; Yoo, Ji Yeoun Abstract: To characterize continuous video electroencephalogram (VEEG) findings of hospitalized COVID-19 patients. We…
Read MoreEffects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial.
Link: https://doi.org/10.1001/jamanetworkopen.2022.1048 Authors: Nadkarni, Girish N; Fei, Kezhen; Ramos, Michelle A; Hauser, Diane; Bagiella, Emilia; Ellis, Stephen B; Sanderson, Saskia; Scott, Stuart A; Sabin, Tatiana; Madden, Ebony; Cooper, Richard; Pollak, Martin; Calman, Neil; Bottinger, Erwin P; Horowitz, Carol R Abstract: Risk variants in the apolipoprotein L1 (APOL1 [OMIM 603743]) gene on chromosome 22 are common…
Read MoreDoes Bariatric Surgery Prior to Primary Total Knee Arthroplasty Improve Outcomes?
Link: https://doi.org/S0883-5403(22)00199-1 Authors: Ryan, Sean P; Couch, Cory G; Duong, Stephanie Q; Taunton, Michael J; Lewallen, David G; Berry, Daniel J; Abdel, Matthew P Abstract: Recent advancements in bariatric surgical techniques have increased its utilization for the management of morbid obesity prior to total knee arthroplasty (TKA). We hypothesized that bariatric surgery prior to primary…
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