Posts by Amir Safavi
Prognostic value of polygenic risk scores for adults with psychosis.
Link: https://doi.org/10.1038/s41591-021-01475-7 Authors: Landi, Isotta; Kaji, Deepak A; Cotter, Liam; Van Vleck, Tielman; Belbin, Gillian; Preuss, Michael; Loos, Ruth J F; Kenny, Eimear; Glicksberg, Benjamin S; Beckmann, Noam D; O’Reilly, Paul; Schadt, Eric E; Achtyes, Eric D; Buckley, Peter F; Lehrer, Douglas; Malaspina, Dolores P; McCarroll, Steven A; Rapaport, Mark H; Fanous, Ayman H; Pato,…
Read MorePhe2vec: Automated disease phenotyping based on unsupervised embeddings from electronic health records.
Link: https://doi.org/10.1016/j.patter.2021.100337 Authors: De Freitas, Jessica K; Johnson, Kipp W; Golden, Eddye; Nadkarni, Girish N; Dudley, Joel T; Bottinger, Erwin P; Glicksberg, Benjamin S; Miotto, Riccardo Abstract: Robust phenotyping of patients from electronic health records (EHRs) at scale is a challenge in clinical informatics. Here, we introduce Phe2vec, an automated framework for disease phenotyping from…
Read MoreMachine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019.
Link: https://doi.org/10.1097/CCE.0000000000000515 Authors: Churpek, Matthew M; Gupta, Shruti; Spicer, Alexandra B; Hayek, Salim S; Srivastava, Anand; Chan, Lili; Melamed, Michal L; Brenner, Samantha K; Radbel, Jared; Madhani-Lovely, Farah; Bhatraju, Pavan K; Bansal, Anip; Green, Adam; Goyal, Nitender; Shaefi, Shahzad; Parikh, Chirag R; Semler, Matthew W; Leaf, David E; , Abstract: Critically ill patients with coronavirus…
Read MoreDevelopment and validation of techniques for phenotyping ST-elevation myocardial infarction encounters from electronic health records.
Link: https://doi.org/10.1093/jamiaopen/ooab068 Authors: Somani, Sulaiman; Yoffie, Stephen; Teng, Shelly; Havaldar, Shreyas; Nadkarni, Girish N; Zhao, Shan; Glicksberg, Benjamin S Abstract: Classifying hospital admissions into various acute myocardial infarction phenotypes in electronic health records (EHRs) is a challenging task with strong research implications that remains unsolved. To our knowledge, this study is the first study to…
Read MoreDownregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Link: https://doi.org/10.1038/s41467-021-24981-1 Authors: Beckmann, Noam D; Comella, Phillip H; Cheng, Esther; Lepow, Lauren; Beckmann, Aviva G; Tyler, Scott R; Mouskas, Konstantinos; Simons, Nicole W; Hoffman, Gabriel E; Francoeur, Nancy J; Del Valle, Diane Marie; Kang, Gurpawan; Do, Anh; Moya, Emily; Wilkins, Lillian; Le Berichel, Jessica; Chang, Christie; Marvin, Robert; Calorossi, Sharlene; Lansky, Alona; Walker, Laura;…
Read MoreAlbuminuria Testing in Hypertension and Diabetes: An Individual-Participant Data Meta-Analysis in a Global Consortium.
Link: https://doi.org/10.1161/HYPERTENSIONAHA.121.17323 Authors: Shin, Jung-Im; Chang, Alex R; Grams, Morgan E; Coresh, Josef; Ballew, Shoshana H; Surapaneni, Aditya; Matsushita, Kunihiro; Bilo, Henk J G; Carrero, Juan J; Chodick, Gabriel; Daratha, Kenn B; Jassal, Simerjot K; Nadkarni, Girish N; Nelson, Robert G; Nowak, Christoph; Stempniewicz, Nikita; Sumida, Keiichi; Traynor, Jamie P; Woodward, Mark; Sang, Yingying; Gansevoort,…
Read MoreObesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US.
Link: https://doi.org/10.1002/oby.23245 Authors: Friedman, Allon N; Guirguis, John; Kapoor, Rajat; Gupta, Shruti; Leaf, David E; Timsina, Lava R; , Abstract: This study aimed to determine whether obesity is independently associated with major adverse clinical outcomes and inflammatory and thrombotic markers in critically ill patients with COVID-19. The primary outcome was in-hospital mortality in adults with…
Read MoreAcute Kidney Injury in Patients Hospitalized With COVID-19 in New York City: Temporal Trends From March 2020 to April 2021.
Link: https://doi.org/10.1016/j.xkme.2021.06.008 Authors: Dellepiane, Sergio; Vaid, Akhil; Jaladanki, Suraj K; Coca, Steven; Fayad, Zahi A; Charney, Alexander W; Bottinger, Erwin P; He, John Cijiang; Glicksberg, Benjamin S; Chan, Lili; Nadkarni, Girish Abstract:
Read MorePerformance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States.
Link: https://doi.org/10.1016/j.xcrm.2021.100376 Authors: Jezmir, Julia L; Bharadwaj, Maheetha; Chaitoff, Alexander; Diephuis, Bradford; Crowley, Conor P; Kishore, Sandeep P; Goralnick, Eric; Merriam, Louis T; Milliken, Aimee; Rhee, Chanu; Sadovnikoff, Nicholas; Shah, Sejal B; Gupta, Shruti; Leaf, David E; Feldman, William B; Kim, Edy Y; , Abstract: Many US states published crisis standards of care (CSC) guidelines…
Read MoreRare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.
Link: https://doi.org/10.1161/CIRCGEN.120.003300 Authors: Choi, Seung Hoan; Jurgens, Sean J; Haggerty, Christopher M; Hall, Amelia W; Halford, Jennifer L; Morrill, Valerie N; Weng, Lu-Chen; Lagerman, Braxton; Mirshahi, Tooraj; Pettinger, Mary; Guo, Xiuqing; Lin, Henry J; Alonso, Alvaro; Soliman, Elsayed Z; Kornej, Jelena; Lin, Honghuang; Moscati, Arden; Nadkarni, Girish N; Brody, Jennifer A; Wiggins, Kerri L; Cade,…
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