Posts by Amir Safavi
Human and mouse essentiality screens as a resource for disease gene discovery.
Link: https://doi.org/10.1038/s41467-020-14284-2 Authors: Cacheiro, Pilar; Muñoz-Fuentes, Violeta; Murray, Stephen A; Dickinson, Mary E; Bucan, Maja; Nutter, Lauryl M J; Peterson, Kevin A; Haselimashhadi, Hamed; Flenniken, Ann M; Morgan, Hugh; Westerberg, Henrik; Konopka, Tomasz; Hsu, Chih-Wei; Christiansen, Audrey; Lanza, Denise G; Beaudet, Arthur L; Heaney, Jason D; Fuchs, Helmut; Gailus-Durner, Valerie; Sorg, Tania; Prochazka, Jan; Novosadova,…
Read MoreThe epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Link: https://doi.org/10.1038/s41467-019-14082-5 Authors: Inda, Maria Carmen; Joshi, Suhasini; Wang, Tai; Bolaender, Alexander; Gandu, Srinivasa; Koren Iii, John; Che, Alicia Yue; Taldone, Tony; Yan, Pengrong; Sun, Weilin; Uddin, Mohammad; Panchal, Palak; Riolo, Matthew; Shah, Smit; Barlas, Afsar; Xu, Ke; Chan, Lon Yin L; Gruzinova, Alexandra; Kishinevsky, Sarah; Studer, Lorenz; Fossati, Valentina; Noggle, Scott A; White, Julie…
Read MoreExclusion of Persons with Kidney Disease in Trials of Peripheral Artery Disease: A Systematic Review of Randomized Trials.
Link: https://doi.org/10.2215/CJN.10330819 Authors: Wen, Yumeng; Potok, O Alison; Wei, Xin; Paranjpe, Ishan; Chan, Lili; Malhotra, Rakesh; Coca, Steven; Narula, Jagat; Olin, Jeffrey W; Nadkarni, Girish N; Garimella, Pranav S Abstract:
Read MoreNatural language processing of electronic health records is superior to billing codes to identify symptom burden in hemodialysis patients.
Link: https://doi.org/S0085-2538(19)31116-0 Authors: Chan, Lili; Beers, Kelly; Yau, Amy A; Chauhan, Kinsuk; Duffy, Áine; Chaudhary, Kumardeep; Debnath, Neha; Saha, Aparna; Pattharanitima, Pattharawin; Cho, Judy; Kotanko, Peter; Federman, Alex; Coca, Steven G; Van Vleck, Tielman; Nadkarni, Girish N Abstract: Symptoms are common in patients on maintenance hemodialysis but identification is challenging. New informatics approaches including natural…
Read MoreTarget genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Link: https://doi.org/10.1038/s41588-019-0504-x Authors: Tin, Adrienne; Marten, Jonathan; Halperin Kuhns, Victoria L; Li, Yong; Wuttke, Matthias; Kirsten, Holger; Sieber, Karsten B; Qiu, Chengxiang; Gorski, Mathias; Yu, Zhi; Giri, Ayush; Sveinbjornsson, Gardar; Li, Man; Chu, Audrey Y; Hoppmann, Anselm; O’Connor, Luke J; Prins, Bram; Nutile, Teresa; Noce, Damia; Akiyama, Masato; Cocca, Massimiliano; Ghasemi, Sahar; van der Most,…
Read MoreNational Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support.
Link: https://doi.org/S0002-9149(19)30999-3 Authors: Miller, P Elliott; Patel, Shanti; Saha, Aparna; Guha, Avirup; Pawar, Sumeet; Poojary, Priti; Ratnani, Parita; Chan, Lili; Kamholz, Stephan L; Alviar, Carlos L; van Diepen, Sean; Nasir, Khurram; Ahmad, Tariq; Nadkarni, Girish N; Desai, Nihar R Abstract:
Read MoreThe Association of Fenofibrate with Kidney Tubular Injury in a Subgroup of Participants in the ACCORD Trial.
Link: https://doi.org/10.2215/CJN.00370119 Authors: Chauhan, Kinsuk; Nadkarni, Girish N; Debnath, Neha; Chan, Lili; Saha, Aparna; Garg, Amit X; Parikh, Chirag R; Coca, Steven G Abstract:
Read MoreTrends and Racial Disparities of Palliative Care Use among Hospitalized Patients with ESKD on Dialysis.
Link: https://doi.org/10.1681/ASN.2018121256 Authors: Wen, Yumeng; Jiang, Changchuan; Koncicki, Holly M; Horowitz, Carol R; Cooper, Richard S; Saha, Aparna; Coca, Steven G; Nadkarni, Girish N; Chan, Lili Abstract: Study findings show that although palliative care decreases symptom burden, it is still underused in patients with ESKD. Little is known about disparity in use of palliative care…
Read MoreComparison of Rotational with Orbital Atherectomy During Percutaneous Coronary Intervention for Coronary Artery Calcification: A Systematic Review and Meta-Analysis.
Link: https://doi.org/S1553-8389(19)30431-2 Authors: Sawant, Abhishek C; Panchal, Hemang; Radadiya, Dhruvil; Pomakov, Alexander; Tse, Gary; Liu, Tong; Sridhara, Srilekha; Rodriguez, Janelle; Prakash, Meghana Prakash Hiriyur; Kanwar, Nidhi; Kumar, Arnav; Banerjee, Kinjal; Wiesner, Philipp; Pershad, Ashish Abstract: Percutaneous coronary intervention (PCI) outcomes for patients with significant calcification have been consistently inferior compared to patients without significant calcification.…
Read MoreAugmented intelligence with natural language processing applied to electronic health records for identifying patients with non-alcoholic fatty liver disease at risk for disease progression.
Link: https://doi.org/S1386-5056(19)30269-2 Authors: Van Vleck, Tielman T; Chan, Lili; Coca, Steven G; Craven, Catherine K; Do, Ron; Ellis, Stephen B; Kannry, Joseph L; Loos, Ruth J F; Bonis, Peter A; Cho, Judy; Nadkarni, Girish N Abstract: Electronic health record (EHR) systems contain structured data (such as diagnostic codes) and unstructured data (clinical documentation). Clinical insights…
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