Posts by Amir Safavi
Machine Learning in Glomerular Diseases: Promise for Precision Medicine.
Link: https://doi.org/S0272-6386(19)30714-0 Authors: Nadkarni, Girish N; Chaudhary, Kumardeep; Coca, Steven G Abstract:
Read MoreA catalog of genetic loci associated with kidney function from analyses of a million individuals.
Link: https://doi.org/10.1038/s41588-019-0407-x Authors: Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B; Feitosa, Mary F; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar; Xu, Yizhe; Horn, Katrin; Noce, Damia; van der…
Read MoreGenetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study.
Link: https://doi.org/10.3389/fgene.2019.00494 Authors: Lin, Bridget M; Nadkarni, Girish N; Tao, Ran; Graff, Mariaelisa; Fornage, Myriam; Buyske, Steven; Matise, Tara C; Highland, Heather M; Wilkens, Lynne R; Carlson, Christopher S; Park, S Lani; Setiawan, V Wendy; Ambite, Jose Luis; Heiss, Gerardo; Boerwinkle, Eric; Lin, Dan-Yu; Morris, Andrew P; Loos, Ruth J F; Kooperberg, Charles; North, Kari…
Read MorePrediction of the 1-Year Risk of Incident Lung Cancer: Prospective Study Using Electronic Health Records from the State of Maine.
Link: https://doi.org/10.2196/13260 Authors: Wang, Xiaofang; Zhang, Yan; Hao, Shiying; Zheng, Le; Liao, Jiayu; Ye, Chengyin; Xia, Minjie; Wang, Oliver; Liu, Modi; Weng, Ching Ho; Duong, Son Q; Jin, Bo; Alfreds, Shaun T; Stearns, Frank; Kanov, Laura; Sylvester, Karl G; Widen, Eric; McElhinney, Doff B; Ling, Xuefeng B Abstract: Lung cancer is the leading cause of…
Read MoreDeterminants of Depressive Symptoms at 1 Year Following ICU Discharge in Survivors of ≥ 7 Days of Mechanical Ventilation: Results From the RECOVER Program, a Secondary Analysis of a Prospective Multicenter Cohort Study.
Link: https://doi.org/S0012-3692(19)31046-3 Authors: Hamilton, Mika; Tomlinson, George; Chu, Leslie; Robles, Priscila; Matte, Andrea; Burns, Stacey; Thomas, Claire; Lamontagne, Francois; Adhikari, Neill K J; Ferguson, Niall; Friedrich, Jan O; Rudkowski, Jill C; Skrobik, Yoanna; Meggison, Hilary; Cameron, Jill; Herridge, Margaret; , ; , Abstract: Moderate to severe depressive symptoms occur in up to one-third of patients…
Read MoreApolipoprotein L1, Cardiovascular Disease and Hypertension: More Questions than Answers.
Link: https://doi.org/S0733-8651(19)30035-9 Authors: Patel, Niralee; Nadkarni, Girish N Abstract: Ethnic disparities in health outcomes exist among multiple complex diseases especially cardiovascular disease, hypertension, and kidney disease. Recent discoveries in genetics have taught us that these disparities go beyond environmental and socioeconomic factors. The discovery of ethnic-specific risk variants in the Apolipoprotein L1 (APOL1) gene on…
Read MoreRate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients.
Link: https://doi.org/10.2215/CJN.10640918 Authors: Chauhan, Kinsuk; Pattharanitima, Pattharawin; Patel, Niralee; Duffy, Aine; Saha, Aparna; Chaudhary, Kumardeep; Debnath, Neha; Van Vleck, Tielman; Chan, Lili; Nadkarni, Girish N; Coca, Steven G Abstract: Hypernatremia is common in hospitalized, critically ill patients. Although there are no clear guidelines on sodium correction rate for hypernatremia, some studies suggest a reduction rate…
Read MoreAdiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.
Link: https://doi.org/10.1136/bmj.k5301 Authors: Chang, Alex R; Grams, Morgan E; Ballew, Shoshana H; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D; Roderick, Paul J; Valdivielso, Jose M; Visseren, Frank L J; Zhang, Luxia; Gansevoort, Ron…
Read MorePatient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.
Link: https://doi.org/S1934-5909(18)30554-X Authors: Hu, Wenxiang; Jiang, Chunjie; Guan, Dongyin; Dierickx, Pieterjan; Zhang, Rong; Moscati, Arden; Nadkarni, Girish N; Steger, David J; Loos, Ruth J F; Hu, Cheng; Jia, Weiping; Soccio, Raymond E; Lazar, Mitchell A Abstract: Thiazolidinedione drugs (TZDs) target the transcriptional activity of peroxisome proliferator activated receptor γ (PPARγ) to reverse insulin resistance in…
Read MoreChange in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies.
Link: https://doi.org/S2213-8587(18)30313-9 Authors: Coresh, Josef; Heerspink, Hiddo J L; Sang, Yingying; Matsushita, Kunihiro; Arnlov, Johan; Astor, Brad C; Black, Corri; Brunskill, Nigel J; Carrero, Juan-Jesus; Feldman, Harold I; Fox, Caroline S; Inker, Lesley A; Ishani, Areef; Ito, Sadayoshi; Jassal, Simerjot; Konta, Tsuneo; Polkinghorne, Kevan; Romundstad, Solfrid; Solbu, Marit D; Stempniewicz, Nikita; Stengel, Benedicte; Tonelli, Marcello;…
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