Population-Based Penetrance of Deleterious Clinical Variants.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1001/jama.2021.23686 Authors: Forrest, Iain S; Chaudhary, Kumardeep; Vy, Ha My T; Petrazzini, Ben O; Bafna, Shantanu; Jordan, Daniel M; Rocheleau, Ghislain; Loos, Ruth J F; Nadkarni, Girish N; Cho, Judy H; Do, Ron Abstract: Population-based assessment of disease risk associated with gene variants informs clinical decisions and risk stratification approaches. To evaluate the population-based…

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Estimated Glomerular Filtration Rate, Albuminuria, and Adverse Outcomes: An Individual-Participant Data Meta-Analysis.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1001/jama.2023.17002 Authors: , ; Grams, Morgan E; Coresh, Josef; Matsushita, Kunihiro; Ballew, Shoshana H; Sang, Yingying; Surapaneni, Aditya; Alencar de Pinho, Natalia; Anderson, Amanda; Appel, Lawrence J; Ärnlöv, Johan; Azizi, Fereidoun; Bansal, Nisha; Bell, Samira; Bilo, Henk J G; Brunskill, Nigel J; Carrero, Juan J; Chadban, Steve; Chalmers, John; Chen, Jing; Ciemins, Elizabeth; Cirillo,…

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Elbow Fracture-Dislocations: Determining Treatment Strategies.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S0749-0712(20)30095-0 Authors: Luchetti, Timothy J; Abbott, Emily E; Baratz, Mark E Abstract: Elbow dislocations represent common injuries. A quarter of these injuries involve at least 1 fracture. The sequel of elbow fracture-dislocations can be fraught with complications, including recurrent instability, posttraumatic arthritis, elbow contracture, and poor functional results. The 3 main patterns of injury…

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Real World Evidence and Clinical Utility of KidneyIntelX on Patients With Early-Stage Diabetic Kidney Disease: Interim Results on Decision Impact and Outcomes.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1177/21501319221138196 Authors: Tokita, Joji; Vega, Aida; Sinfield, Catherine; Naik, Nidhi; Rathi, Shivani; Martin, Sharlene; Wang, Stephanie; Amoruso, Leonard; Zabetian, Azadeh; Coca, Steven G; Nadkarni, Girish N; Fleming, Fergus; Donovan, Michael J; Fields, Robert Abstract: The lack of precision to identify patients with early-stage diabetic kidney disease (DKD) at near-term risk for progressive decline in…

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A Real-World Precision Medicine Program Including the KidneyIntelX Test Effectively Changes Management Decisions and Outcomes for Patients With Early-Stage Diabetic Kidney Disease.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1177/21501319231223437 Authors: Tokita, Joji; Lam, David; Vega, Aida; Wang, Stephanie; Amoruso, Leonard; Muller, Tamara; Naik, Nidhi; Rathi, Shivani; Martin, Sharlene; Zabetian, Azadeh; Liu, Catherine; Sinfield, Catherine; McNicholas, Tony; Fleming, Fergus; Coca, Steven G; Nadkarni, Girish N; Tun, Roger; Kattan, Mike; Donovan, Michael J; Rahim, Arshad K Abstract: The KidneyIntelX is a multiplex, bioprognostic, immunoassay…

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Rheumatoid Arthritis, Cognitive Impairment, and Neuroimaging Biomarkers: Results from the Mayo Clinic Study of Aging.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.3233/JAD-220368 Authors: Vassilaki, Maria; Crowson, Cynthia S; Davis Iii, John M; Duong, Stephanie Q; Jones, David T; Nguyen, Aivi; Mielke, Michelle M; Vemuri, Prashanthi; Myasoedova, Elena Abstract: Observational studies suggested that dementia risk in patients with rheumatoid arthritis (RA) is higher than in the general population. To examine the associations of RA with cognitive…

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Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.2337/dc21-1395 Authors: DiCorpo, Daniel; LeClair, Jessica; Cole, Joanne B; Sarnowski, Chloé; Ahmadizar, Fariba; Bielak, Lawrence F; Blokstra, Anneke; Bottinger, Erwin P; Chaker, Layal; Chen, Yii-Der I; Chen, Ye; de Vries, Paul S; Faquih, Tariq; Ghanbari, Mohsen; Gudmundsdottir, Valborg; Guo, Xiuqing; Hasbani, Natalie R; Ibi, Dorina; Ikram, M Arfan; Kavousi, Maryam; Leonard, Hampton L; Leong,…

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Development and Validation of Prediction Models of Adverse Kidney Outcomes in the Population With and Without Diabetes.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.2337/dc22-0698 Authors: Grams, Morgan E; Brunskill, Nigel J; Ballew, Shoshana H; Sang, Yingying; Coresh, Josef; Matsushita, Kunihiro; Surapaneni, Aditya; Bell, Samira; Carrero, Juan J; Chodick, Gabriel; Evans, Marie; Heerspink, Hiddo J L; Inker, Lesley A; Iseki, Kunitoshi; Kalra, Philip A; Kirchner, H Lester; Lee, Brian J; Levin, Adeera; Major, Rupert W; Medcalf, James; Nadkarni,…

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