Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S0092-8674(20)30822-9 Authors: Chen, Ming-Huei; Raffield, Laura M; Mousas, Abdou; Sakaue, Saori; Huffman, Jennifer E; Moscati, Arden; Trivedi, Bhavi; Jiang, Tao; Akbari, Parsa; Vuckovic, Dragana; Bao, Erik L; Zhong, Xue; Manansala, Regina; Laplante, Véronique; Chen, Minhui; Lo, Ken Sin; Qian, Huijun; Lareau, Caleb A; Beaudoin, Mélissa; Hunt, Karen A; Akiyama, Masato; Bartz, Traci M; Ben-Shlomo,…

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The Polygenic and Monogenic Basis of Blood Traits and Diseases.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S0092-8674(20)30999-5 Authors: Vuckovic, Dragana; Bao, Erik L; Akbari, Parsa; Lareau, Caleb A; Mousas, Abdou; Jiang, Tao; Chen, Ming-Huei; Raffield, Laura M; Tardaguila, Manuel; Huffman, Jennifer E; Ritchie, Scott C; Megy, Karyn; Ponstingl, Hannes; Penkett, Christopher J; Albers, Patrick K; Wigdor, Emilie M; Sakaue, Saori; Moscati, Arden; Manansala, Regina; Lo, Ken Sin; Qian, Huijun; Akiyama,…

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Metabolite Biomarkers of CKD Progression in Children.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.2215/CJN.00220121 Authors: Denburg, Michelle R; Xu, Yunwen; Abraham, Alison G; Coresh, Josef; Chen, Jingsha; Grams, Morgan E; Feldman, Harold I; Kimmel, Paul L; Rebholz, Casey M; Rhee, Eugene P; Vasan, Ramachandran S; Warady, Bradley A; Furth, Susan L; , Abstract: Metabolomics facilitates the discovery of biomarkers and potential therapeutic targets for CKD progression. We…

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Continuous Kidney Replacement Therapy of the Future: Innovations in Information Technology, Data Analytics, and Quality Assurance Systems.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S1548-5595(21)00031-8 Authors: Neyra, Javier A; Nadkarni, Girish N Abstract: Continuous kidney replacement therapy is commonly used in the critically ill population. Despite the recent development in continuous kidney replacement therapy technology and clinical informatics, many aspects of continuous kidney replacement therapy delivery are still not fully standardized, and quality assurance programs for the provision…

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Natural Language Processing in Nephrology.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/S1548-5595(22)00128-8 Authors: Van Vleck, Tielman T; Farrell, Douglas; Chan, Lili Abstract: Unstructured data in the electronic health records contain essential patient information. Natural language processing (NLP), teaching a computer to read, allows us to tap into these data without needing the time and effort of manual chart abstraction. The core first step for all…

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Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1056/NEJMoa2021712 Authors: Garrelfs, Sander F; Frishberg, Yaacov; Hulton, Sally A; Koren, Michael J; O’Riordan, William D; Cochat, Pierre; Deschênes, Georges; Shasha-Lavsky, Hadas; Saland, Jeffrey M; Van’t Hoff, William G; Fuster, Daniel G; Magen, Daniella; Moochhala, Shabbir H; Schalk, Gesa; Simkova, Eva; Groothoff, Jaap W; Sas, David J; Meliambro, Kristin A; Lu, Jiandong; Sweetser, Marianne…

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Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors.

By Amir Safavi | March 5, 2023 |

Link: https://doi.org/10.1038/s41586-018-0164-5 Authors: Chan, Lai N; Chen, Zhengshan; Braas, Daniel; Lee, Jae-Woong; Xiao, Gang; Geng, Huimin; Cosgun, Kadriye Nehir; Hurtz, Christian; Shojaee, Seyedmehdi; Cazzaniga, Valeria; Schjerven, Hilde; Ernst, Thomas; Hochhaus, Andreas; Kornblau, Steven M; Konopleva, Marina; Pufall, Miles A; Cazzaniga, Giovanni; Liu, Grace J; Milne, Thomas A; Koeffler, H Phillip; Ross, Theodora S; Sánchez-García, Isidro;…

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