4research
Clinical Utility of KidneyIntelX in Early Stages of Diabetic Kidney Disease in the CANVAS Trial.
Link: https://doi.org/10.1159/000519920 Authors: Lam, David; Nadkarni, Girish N; Mosoyan, Gohar; Neal, Bruce; Mahaffey, Kenneth W; Rosenthal, Norman; Hansen, Michael K; Heerspink, Hiddo J L; Fleming, Fergus; Coca, Steven G Abstract: KidneyIntelX is a composite risk score, incorporating biomarkers and clinical variables for predicting progression of diabetic kidney disease (DKD). The utility of this score in…
Read MoreAssociation of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19.
Link: https://doi.org/10.1177/08850666211067509 Authors: Keene, Adam B; Admon, Andrew J; Brenner, Samantha K; Gupta, Shruti; Lazarous, Deepa; Leaf, David E; Gershengorn, Hayley B; , Abstract: To determine whether surge conditions were associated with increased mortality. Multicenter cohort study. U.S. ICUs participating in STOP-COVID. Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July…
Read MoreIdentification of patients at risk of new onset heart failure: Utilizing a large statewide health information exchange to train and validate a risk prediction model.
Link: https://doi.org/10.1371/journal.pone.0260885 Authors: Duong, Son Q; Zheng, Le; Xia, Minjie; Jin, Bo; Liu, Modi; Li, Zhen; Hao, Shiying; Alfreds, Shaun T; Sylvester, Karl G; Widen, Eric; Teuteberg, Jeffery J; McElhinney, Doff B; Ling, Xuefeng B Abstract: New-onset heart failure (HF) is associated with poor prognosis and high healthcare utilization. Early identification of patients at increased…
Read MorePrevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19.
Link: https://doi.org/10.1159/000520355 Authors: Chauhan, Kinsuk; Pattharanitima, Pattharawin; Piani, Federica; Johnson, Richard J; Uribarri, Jaime; Chan, Lili; Coca, Steven G Abstract: Coronavirus 2019 (COVID-19) can increase catabolism and result in hyperuricemia. Uric acid (UA) potentially causes kidney damage by alteration of renal autoregulation, inhibition of endothelial cell proliferation, cell apoptosis, activation of the pro-inflammatory cascade, and…
Read MoreThe power of genetic diversity in genome-wide association studies of lipids.
Link: https://doi.org/10.1038/s41586-021-04064-3 Authors: Graham, Sarah E; Clarke, Shoa L; Wu, Kuan-Han H; Kanoni, Stavroula; Zajac, Greg J M; Ramdas, Shweta; Surakka, Ida; Ntalla, Ioanna; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Hwang, Mi Yeong; Han, Sohee; Narita, Akira; Choudhury, Ananyo; Bentley, Amy R; Ekoru, Kenneth; Verma, Anurag; Trivedi, Bhavi; Martin, Hilary C;…
Read MoreDevelopment of a machine learning model using electrocardiogram signals to improve acute pulmonary embolism screening.
Link: https://doi.org/10.1093/ehjdh/ztab101 Authors: Somani, Sulaiman S; Honarvar, Hossein; Narula, Sukrit; Landi, Isotta; Lee, Shawn; Khachatoorian, Yeraz; Rehmani, Arsalan; Kim, Andrew; De Freitas, Jessica K; Teng, Shelly; Jaladanki, Suraj; Kumar, Arvind; Russak, Adam; Zhao, Shan P; Freeman, Robert; Levin, Matthew A; Nadkarni, Girish N; Kagen, Alexander C; Argulian, Edgar; Glicksberg, Benjamin S Abstract: Clinical scoring systems…
Read MoreArtificial Intelligence for AKI!Now: Let’s Not Await Plato’s Utopian Republic.
Link: https://doi.org/10.34067/KID.0003472021 Authors: Soranno, Danielle E; Bihorac, Azra; Goldstein, Stuart L; Kashani, Kianoush B; Menon, Shina; Nadkarni, Girish N; Neyra, Javier A; Pannu, Neesh I; Singh, Karandeep; Cerda, Jorge; Koyner, Jay L; , Abstract:
Read MoreDeciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses.
Link: https://doi.org/10.1038/s41467-021-26771-1 Authors: Contreras-Trujillo, Humberto; Eerdeng, Jiya; Akre, Samir; Jiang, Du; Contreras, Jorge; Gala, Basia; Vergel-Rodriguez, Mary C; Lee, Yeachan; Jorapur, Aparna; Andreasian, Areen; Harton, Lisa; Bramlett, Charles S; Nogalska, Anna; Xiao, Gang; Lee, Jae-Woong; Chan, Lai N; Müschen, Markus; Merchant, Akil A; Lu, Rong Abstract: Cellular heterogeneity is a major cause of treatment resistance…
Read MoreIdentification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants.
Link: https://doi.org/S0002-9297(21)00384-0 Authors: Sevim Bayrak, Cigdem; Stein, David; Jain, Aayushee; Chaudhary, Kumardeep; Nadkarni, Girish N; Van Vleck, Tielman T; Puel, Anne; Boisson-Dupuis, Stephanie; Okada, Satoshi; Stenson, Peter D; Cooper, David N; Schlessinger, Avner; Itan, Yuval Abstract: Identifying whether a given genetic mutation results in a gene product with increased (gain-of-function; GOF) or diminished (loss-of-function; LOF)…
Read MoreDerivation and Validation of Genome-Wide Polygenic Score for Ischemic Heart Failure.
Link: https://doi.org/10.1161/JAHA.121.021916 Authors: Paranjpe, Ishan; Tsao, Noah L; De Freitas, Jessica K; Judy, Renae; Chaudhary, Kumardeep; Forrest, Iain S; Jaladanki, Suraj K; Paranjpe, Manish; Sharma, Pranav; , ; , ; Glicksberg, Benjamin S; Narula, Jagat; Do, Ron; Damrauer, Scott M; Nadkarni, Girish N Abstract:
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