Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus.

Link: https://doi.org/10.1101/2023.07.25.23293180 Authors: Kwak, Soo Heon; Hernandez-Cancela, Ryan B; DiCorpo, Daniel A; Condon, David E; Merino, Jordi; Wu, Peitao; Brody, Jennifer A; Yao, Jie; Guo, Xiuqing; Ahmadizar, Fariba; Meyer, Mariah; Sincan, Murat; Mercader, Josep M; Lee, Sujin; Haessler, Jeffrey; Vy, Ha My T; Lin, Zhaotong; Armstrong, Nicole D; Gu, Shaopeng; Tsao, Noah L; Lange, Leslie…

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A Novel ECG-Based Deep Learning Algorithm to Predict Cardiomyopathy in Patients With Premature Ventricular Complexes.

Link: https://doi.org/S2405-500X(23)00339-0 Authors: Lampert, Joshua; Vaid, Akhil; Whang, William; Koruth, Jacob; Miller, Marc A; Langan, Marie-Noelle; Musikantow, Daniel; Turagam, Mohit; Maan, Abhishek; Kawamura, Iwanari; Dukkipati, Srinivas; Nadkarni, Girish N; Reddy, Vivek Y Abstract: Premature ventricular complexes (PVCs) are prevalent and, although often benign, they may lead to PVC-induced cardiomyopathy. We created a deep-learning algorithm to…

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Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation.

Link: https://doi.org/S0939-4753(23)00283-1 Authors: Kittrell, Hannah D; DiMenna, Fred J; Arad, Avigdor D; Oh, Wonsuk; Hofer, Ira; Walker, Ryan W; Loos, Ruth J F; Albu, Jeanine B; Nadkarni, Girish N Abstract: Our results indicate that estimated “fat-burning” heart rate zones are inappropriate for prescribing exercise to elicit MLO and we recommend direct individual exercise lipid oxidation…

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Deep Learning on Electrocardiograms for Prediction of In-hospital Intradialytic Hypotension in Patients with ESKD.

Link: https://doi.org/10.34067/KID.0000000000000208 Authors: Vaid, Akhil; Takkavatakarn, Kullaya; Divers, Jasmin; Charytan, David M; Chan, Lili; Nadkarni, Girish N Abstract: Intradialytic hypotension is common in patients who are on hemodialysis. We applied deep learning techniques to ECGs to predict patients at risk of IDH. The performance of the model was good with an AUC of 0.763 and…

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Interatrial Block Association With Adverse Cardiovascular Outcomes in Patients Without a History of Atrial Fibrillation.

Link: https://doi.org/S2405-500X(23)00254-2 Authors: Lampert, Joshua; Power, David; Havaldar, Shreyas; Govindarajulu, Usha; Kawamura, Iwanari; Maan, Abhishek; Miller, Marc A; Menon, Kartikeya; Koruth, Jacob; Whang, William; Bagiella, Emilia; Bayes-Genis, Antoni; Musikantow, Daniel; Turagam, Mohit; Bayes de Luna, Antoni; Halperin, Jonathan; Dukkipati, Srinivas R; Vaid, Akhil; Nadkarni, Girish; Glicksberg, Benjamin; Fuster, Valentin; Reddy, Vivek Y Abstract: Interatrial block…

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Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.

Link: https://doi.org/10.1038/s41588-023-01420-z Authors: Klarin, Derek; Devineni, Poornima; Sendamarai, Anoop K; Angueira, Anthony R; Graham, Sarah E; Shen, Ying H; Levin, Michael G; Pirruccello, James P; Surakka, Ida; Karnam, Purushotham R; Roychowdhury, Tanmoy; Li, Yanming; Wang, Minxian; Aragam, Krishna G; Paruchuri, Kaavya; Zuber, Verena; Shakt, Gabrielle E; Tsao, Noah L; Judy, Renae L; Vy, Ha My…

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A foundational vision transformer improves diagnostic performance for electrocardiograms.

Link: https://doi.org/10.1038/s41746-023-00840-9 Authors: Vaid, Akhil; Jiang, Joy; Sawant, Ashwin; Lerakis, Stamatios; Argulian, Edgar; Ahuja, Yuri; Lampert, Joshua; Charney, Alexander; Greenspan, Hayit; Narula, Jagat; Glicksberg, Benjamin; Nadkarni, Girish N Abstract: The electrocardiogram (ECG) is a ubiquitous diagnostic modality. Convolutional neural networks (CNNs) applied towards ECG analysis require large sample sizes, and transfer learning approaches for biomedical…

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Quantitative prediction of right ventricular and size and function from the electrocardiogram.

Link: https://doi.org/10.1101/2023.04.25.23289130 Authors: Duong, Son Q; Vaid, Akhil; Vy, Ha My Thi; Butler, Liam R; Lampert, Joshua; Pass, Robert H; Charney, Alexander W; Narula, Jagat; Khera, Rohan; Greenspan, Hayit; Gelb, Bruce D; Do, Ron; Nadkarni, Girish Abstract: Right ventricular ejection fraction (RVEF) and end-diastolic volume (RVEDV) are not readily assessed through traditional modalities. Deep-learning enabled…

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Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP.

Link: https://doi.org/10.1093/eurjpc/zwac176 Authors: Matsushita, Kunihiro; Kaptoge, Stephen; Hageman, Steven H J; Sang, Yingying; Ballew, Shoshana H; Grams, Morgan E; Surapaneni, Aditya; Sun, Luanluan; Arnlov, Johan; Bozic, Milica; Brenner, Hermann; Brunskill, Nigel J; Chang, Alex R; Chinnadurai, Rajkumar; Cirillo, Massimo; Correa, Adolfo; Ebert, Natalie; Eckardt, Kai-Uwe; Gansevoort, Ron T; Gutierrez, Orlando; Hadaegh, Farzad; He, Jiang; Hwang,…

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