Posts Tagged ‘Cardiology’
A foundation model for clinician-centered drug repurposing.
Link: https://doi.org/10.1101/2023.03.19.23287458 Authors: Huang, Kexin; Chandak, Payal; Wang, Qianwen; Havaldar, Shreyas; Vaid, Akhil; Leskovec, Jure; Nadkarni, Girish; Glicksberg, Benjamin S; Gehlenborg, Nils; Zitnik, Marinka Abstract: Drug repurposing – identifying new therapeutic uses for approved drugs – is often serendipitous and opportunistic, expanding the use of drugs for new diseases. The clinical utility of drug repurposing…
Read MoreEvaluating prompt engineering on GPT-3.5’s performance in USMLE-style medical calculations and clinical scenarios generated by GPT-4.
Link: https://doi.org/10.1038/s41598-024-66933-x Authors: Patel, Dhavalkumar; Raut, Ganesh; Zimlichman, Eyal; Cheetirala, Satya Narayan; Nadkarni, Girish N; Glicksberg, Benjamin S; Apakama, Donald U; Bell, Elijah J; Freeman, Robert; Timsina, Prem; Klang, Eyal Abstract: This study was designed to assess how different prompt engineering techniques, specifically direct prompts, Chain of Thought (CoT), and a modified CoT approach, influence…
Read MoreArtificial intelligence-guided detection of under-recognized cardiomyopathies on point-of-care cardiac ultrasound: a multi-center study.
Link: https://doi.org/10.1101/2024.03.10.24304044 Authors: Oikonomou, Evangelos K; Vaid, Akhil; Holste, Gregory; Coppi, Andreas; McNamara, Robert L; Baloescu, Cristiana; Krumholz, Harlan M; Wang, Zhangyang; Apakama, Donald J; Nadkarni, Girish N; Khera, Rohan Abstract: Point-of-care ultrasonography (POCUS) enables cardiac imaging at the bedside and in communities but is limited by abbreviated protocols and variation in quality. We developed…
Read MorePostoperative Acute Kidney Injury is Associated with Persistent Renal Dysfunction: A Multicenter Propensity Matched Cohort Study.
Link: https://doi.org/10.1101/2024.06.06.24308455 Authors: Stannard, Blaine; Epstein, Richard H; Gabel, Eilon; Nadkarni, Girish N; Ouyang, Yuxia; Lin, Hung-Mo; Salari, Valiollah; Hofer, Ira S Abstract: The risk of developing a persistent reduction in renal function after postoperative acute kidney injury (pAKI) is not well-established. Perform a multi-center retrospective propensity matched study evaluating whether patients that develop pAKI…
Read MoreHelicopter emergency medical services (HEMS) response to out-of-hospital cardiac arrest (OHCA) in the United States.
Link: https://doi.org/10.1016/j.resplu.2024.100658 Authors: Shekhar, Aditya C; Auten, Michael; Abbott, Ethan E; McCartin, Michael; Blumen, Ira J Abstract: Helicopter emergency medical services (HEMS) are used in the United States and globally to respond to patients with critical illness and victims of traumatic injury. Relatively limited research has examined their role in responding to out-of-hospital cardiac arrests…
Read MoreMachine Learning Quantification of Pulmonary Regurgitation Fraction from Echocardiography.
Link: https://doi.org/10.1007/s00246-024-03511-y Authors: Cohen, Jennifer; Duong, Son Q; Arivazhagan, Naveen; Barris, David M; Bebiya, Surkhay; Castaldo, Rosalie; Gayanilo, Marjorie; Hopkins, Kali; Kailas, Maya; Kong, Grace; Ma, Xiye; Marshall, Molly; Paul, Erin A; Tan, Melanie; Yau, Jen Lie; Nadkarni, Girish N; Ezon, David Abstract: Assessment of pulmonary regurgitation (PR) guides treatment for patients with congenital heart…
Read MoreInfant out-of-hospital cardiac arrest during nights and weekends.
Link: https://doi.org/S0735-6757(24)00224-9 Authors: Shekhar, Aditya C; Childers, Molly K; Abbott, Ethan E; Kimbrell, Joshua; Coute, Ryan A; Mader, Timothy J; Mann, N Clay; Madhok, Manu Abstract: A growing body of evidence suggests outcomes for cardiac arrest in adults are worse during nights and weekends when compared with daytime and weekdays. Similar research has not yet…
Read MoreCharacterizing cell type specific transcriptional differences between the living and postmortem human brain.
Link: https://doi.org/10.1101/2024.05.01.24306590 Authors: Vornholt, Eric; Liharska, Lora E; Cheng, Esther; Hashemi, Alice; Park, You Jeong; Ziafat, Kimia; Wilkins, Lillian; Silk, Hannah; Linares, Lisa M; Thompson, Ryan C; Sullivan, Brendan; Moya, Emily; Nadkarni, Girish N; Sebra, Robert; Schadt, Eric E; Kopell, Brian H; Charney, Alexander W; Beckmann, Noam D Abstract: Single-nucleus RNA sequencing (snRNA-seq) is often…
Read MoreNeuropsychiatric complications of coronavirus disease 2019: Mount Sinai Health System cohort study.
Link: https://doi.org/10.1007/s00415-024-12370-9 Authors: Gururangan, Kapil; Peschansky, Veronica J; Van Hyfte, Grace; Agarwal, Parul; Blank, Leah J; Mathew, Brian; Goldstein, Jonathan; Kwon, Churl-Su; McCarthy, Louise; Cohen, Ariella; Chan, Andy Ho Wing; Deng, Pojen; Dhamoon, Mandip; Gutzwiller, Eveline; Hao, Qing; He, Celestine; Klenofsky, Britany; Lemus, Hernan Nicolas; Marcuse, Lara; Navis, Allison; Heredia Nunez, Wilson D; Luckey, Mallory…
Read MoreThe Association of Racial Residential Segregation and Survival After Out-of-Hospital Cardiac Arrest in the United States.
Link: https://doi.org/10.1101/2024.04.22.24306186 Authors: Abbott, Ethan E; Buckler, David G; Shekhar, Aditya C; Landry, Elizabeth; Abella, Benjamin S; Richardson, Lynne D; Zebrowski, Alexis M; , Abstract: Residential segregation has been identified as drivers of disparities in health outcomes, but further work is needed to understand this association with clinical outcomes for out-of-hospital cardiac arrest (OHCA). We…
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