Using sequence clustering to identify clinically relevant subphenotypes in patients with COVID-19 admitted to the intensive care unit.

Link: https://doi.org/10.1093/jamia/ocab252 Authors: Oh, Wonsuk; Jayaraman, Pushkala; Sawant, Ashwin S; Chan, Lili; Levin, Matthew A; Charney, Alexander W; Kovatch, Patricia; Glicksberg, Benjamin S; Nadkarni, Girish N Abstract: The novel coronavirus disease 2019 (COVID-19) has heterogenous clinical courses, indicating that there might be distinct subphenotypes in critically ill patients. Although prior research has identified these subphenotypes,…

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Federated Learning in Health care Using Structured Medical Data.

Link: https://doi.org/S2949-8139(22)00008-8 Authors: Oh, Wonsuk; Nadkarni, Girish N Abstract: The success of machine learning-based studies is largely subjected to accessing a large amount of data. However, accessing such data is typically not feasible within a single health system/hospital. Although multicenter studies are the most effective way to access a vast amount of data, sharing data…

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Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure.

Link: https://doi.org/10.1097/CCM.0000000000004938 Authors: Mathews, Kusum S; Soh, Howard; Shaefi, Shahzad; Wang, Wei; Bose, Sonali; Coca, Steven; Gupta, Shruti; Hayek, Salim S; Srivastava, Anand; Brenner, Samantha K; Radbel, Jared; Green, Adam; Sutherland, Anne; Leonberg-Yoo, Amanda; Shehata, Alexandre; Schenck, Edward J; Short, Samuel A P; Hernán, Miguel A; Chan, Lili; Leaf, David E; , Abstract: Therapies for…

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In Response.

Link: https://doi.org/10.1213/ANE.0000000000003952 Authors: Hofer, Ira S; Levin, Matthew A; Simpao, Allan F; McCormick, Patrick J; Rothman, Brian Abstract:

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Hospital-Level Variation in Death for Critically Ill Patients with COVID-19.

Link: https://doi.org/10.1164/rccm.202012-4547OC Authors: Churpek, Matthew M; Gupta, Shruti; Spicer, Alexandra B; Parker, William F; Fahrenbach, John; Brenner, Samantha K; Leaf, David E; , Abstract: Variation in hospital mortality has been described for coronavirus disease 2019 (COVID-19), but the factors that explain these differences remain unclear. Our objective was to utilize a large, nationally representative dataset…

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Evaluation and management of COVID-19-related severity in people with type 2 diabetes.

Link: https://doi.org/10.1136/bmjdrc-2021-002299 Authors: Wang, Bowen; Glicksberg, Benjamin S; Nadkarni, Girish N; Vashishth, Deepak Abstract: People with type 2 diabetes (T2D) have an increased rate of hospitalization and mortality related to COVID-19. To identify ahead of time those who are at risk of developing severe diseases and potentially in need of intensive care, we investigated the…

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Author Correction: Sampling the host response to SARS-CoV-2 in hospitals under siege.

Link: https://doi.org/10.1038/s41591-021-01247-3 Authors: Charney, Alexander W; Simons, Nicole W; Mouskas, Konstantinos; Lepow, Lauren; Cheng, Esther; Le Berichel, Jessica; Chang, Christie; Marvin, Robert; Del Valle, Diane Marie; Calorossi, Sharlene; Lansky, Alona; Walker, Laura; Patel, Manishkumar; Xie, Hui; Yi, Nancy; Yu, Alex; Kang, Gurpawan; Mendoza, Anthony; Liharska, Lora E; Moya, Emily; Hartnett, Matthew; Hatem, Sandra; Wilkins, Lillian;…

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Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae.

Link: https://doi.org/10.1038/s41591-022-02107-4 Authors: Thompson, Ryan C; Simons, Nicole W; Wilkins, Lillian; Cheng, Esther; Del Valle, Diane Marie; Hoffman, Gabriel E; Cervia, Carlo; Fennessy, Brian; Mouskas, Konstantinos; Francoeur, Nancy J; Johnson, Jessica S; Lepow, Lauren; Le Berichel, Jessica; Chang, Christie; Beckmann, Aviva G; Wang, Ying-Chih; Nie, Kai; Zaki, Nicholas; Tuballes, Kevin; Barcessat, Vanessa; Cedillo, Mario A;…

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Relationship Between Preexisting Cardiovascular Disease and Death and Cardiovascular Outcomes in Critically Ill Patients With COVID-19.

Link: https://doi.org/10.1161/CIRCOUTCOMES.122.008942 Authors: Vasbinder, Alexi; Meloche, Chelsea; Azam, Tariq U; Anderson, Elizabeth; Catalan, Tonimarie; Shadid, Husam; Berlin, Hanna; Pan, Michael; O’Hayer, Patrick; Padalia, Kishan; Blakely, Pennelope; Khaleel, Ibrahim; Michaud, Erinleigh; Huang, Yiyuan; Zhao, Lili; Pop-Busui, Rodica; Gupta, Shruti; Eagle, Kim; Leaf, David E; Hayek, Salim S; , Abstract: Preexisting cardiovascular disease (CVD) is perceived as…

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