The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals.

Link: https://doi.org/10.1186/s12014-022-09371-z Authors: Butler-Laporte, Guillaume; Gonzalez-Kozlova, Edgar; Su, Chen-Yang; Zhou, Sirui; Nakanishi, Tomoko; Brunet-Ratnasingham, Elsa; Morrison, David; Laurent, Laetitia; Afilalo, Jonathan; Afilalo, Marc; Henry, Danielle; Chen, Yiheng; Carrasco-Zanini, Julia; Farjoun, Yossi; Pietzner, Maik; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Bouab, Meriem; Petitjean, Louis; Guzman, Charlotte; Xue, Xiaoqing; Tselios, Chris; Vulesevic, Branka; Adeleye, Olumide; Abdullah, Tala;…

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Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.

Link: https://doi.org/10.1097/CCE.0000000000000755 Authors: Sunderraj, Ashwin; Cho, Chloe; Cai, Xuan; Gupta, Shruti; Mehta, Rupal; Isakova, Tamara; Leaf, David E; Srivastava, Anand; , Abstract: Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between…

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Proteomic Characterization of Acute Kidney Injury in Patients Hospitalized with SARS-CoV2 Infection.

Link: https://doi.org/10.1101/2021.12.09.21267548 Authors: Paranjpe, Ishan; Jayaraman, Pushkala; Su, Chen-Yang; Zhou, Sirui; Chen, Steven; Thompson, Ryan; Del Valle, Diane Marie; Kenigsberg, Ephraim; Zhao, Shan; Jaladanki, Suraj; Chaudhary, Kumardeep; Ascolillo, Steven; Vaid, Akhil; Kumar, Arvind; Kozlova, Edgar; Paranjpe, Manish; O’Hagan, Ross; Kamat, Samir; Gulamali, Faris F; Kauffman, Justin; Xie, Hui; Harris, Joceyln; Patel, Manishkumar; Argueta, Kimberly; Batchelor,…

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Federated Learning in Risk Prediction: A Primer and Application to COVID-19-Associated Acute Kidney Injury.

Link: https://doi.org/10.1159/000525645 Authors: Gulamali, Faris F; Nadkarni, Girish N Abstract: Modern machine learning and deep learning algorithms require large amounts of data; however, data sharing between multiple healthcare institutions is limited by privacy and security concerns. Federated learning provides a functional alternative to the single-institution approach while avoiding the pitfalls of data sharing. In cross-silo…

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COVID-19 Vaccine Uptake Among Patients With Systemic Lupus Erythematosus in the American Midwest: The Lupus Midwest Network (LUMEN).

Link: https://doi.org/10.3899/jrheum.220220 Authors: Chevet, Baptiste; Figueroa-Parra, Gabriel; Yang, Jeffrey X; Hulshizer, Cassondra A; Gunderson, Tina M; Duong, Stephanie Q; Putman, Michael S; Barbour, Kamil E; Crowson, Cynthia S; Duarte-García, Alí Abstract: Patients with systemic lupus erythematosus (SLE) are at higher risk of poor outcomes from coronavirus disease 2019 (COVID-19). The vaccination rate among such patients…

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Evaluation of a machine learning approach utilizing wearable data for prediction of SARS-CoV-2 infection in healthcare workers.

Link: https://doi.org/10.1093/jamiaopen/ooac041 Authors: Hirten, Robert P; Tomalin, Lewis; Danieletto, Matteo; Golden, Eddye; Zweig, Micol; Kaur, Sparshdeep; Helmus, Drew; Biello, Anthony; Pyzik, Renata; Bottinger, Erwin P; Keefer, Laurie; Charney, Dennis; Nadkarni, Girish N; Suarez-Farinas, Mayte; Fayad, Zahi A Abstract: To determine whether a machine learning model can detect SARS-CoV-2 infection from physiological metrics collected from wearable…

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Hispanic ethnicity and mortality among critically ill patients with COVID-19.

Link: https://doi.org/10.1371/journal.pone.0268022 Authors: Ricardo, Ana C; Chen, Jinsong; Toth-Manikowski, Stephanie M; Meza, Natalie; Joo, Min; Gupta, Shruti; Lazarous, Deepa G; Leaf, David E; Lash, James P; , Abstract: Hispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Whether this…

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Whole-genome sequencing reveals host factors underlying critical COVID-19.

Link: https://doi.org/10.1038/s41586-022-04576-6 Authors: Kousathanas, Athanasios; Pairo-Castineira, Erola; Rawlik, Konrad; Stuckey, Alex; Odhams, Christopher A; Walker, Susan; Russell, Clark D; Malinauskas, Tomas; Wu, Yang; Millar, Jonathan; Shen, Xia; Elliott, Katherine S; Griffiths, Fiona; Oosthuyzen, Wilna; Morrice, Kirstie; Keating, Sean; Wang, Bo; Rhodes, Daniel; Klaric, Lucija; Zechner, Marie; Parkinson, Nick; Siddiq, Afshan; Goddard, Peter; Donovan, Sally; Maslove,…

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