Posts by Amir Safavi
Derivation and independent validation of kidneyintelX.dkd: A prognostic test for the assessment of diabetic kidney disease progression.
Link: https://doi.org/10.1111/dom.15273 Authors: Nadkarni, Girish N; Stapleton, Sharon; Takale, Dipti; Edwards, Katherine; Moran, Kara; Mosoyan, Gohar; Hansen, Michael K; Donovan, Michael J; Heerspink, Hiddo J L; Fleming, Fergus; Coca, Steven G Abstract: To develop and validate an updated version of KidneyIntelX (kidneyintelX.dkd) to stratify patients for risk of progression of diabetic kidney disease (DKD) stages…
Read MoreAutomated Identification of Heart Failure with Reduced Ejection Fraction using Deep Learning-based Natural Language Processing.
Link: https://doi.org/10.1101/2023.09.10.23295315 Authors: Nargesi, Arash A; Adejumo, Philip; Dhingra, Lovedeep; Rosand, Benjamin; Hengartner, Astrid; Coppi, Andreas; Benigeri, Simon; Sen, Sounok; Ahmad, Tariq; Nadkarni, Girish N; Lin, Zhenqiu; Ahmad, Faraz S; Krumholz, Harlan M; Khera, Rohan Abstract: The lack of automated tools for measuring care quality has limited the implementation of a national program to assess…
Read MoreDevelopment of a decentralized cohort for studying post-acute sequelae of COVID-19 in India in the Data4life Study.
Link: https://doi.org/10.1038/s43856-023-00349-y Authors: Schilling, Josh; Shokouhi, Sepideh; Montgomery, Aisha; Nadkarni, Girish N; Charney, Alexander W; Shanker, Anil; Singh, Rajbir; Jhaveri, Kenar; Singh, Karandeep S; Khadke, Prashant; Jain, Praduman Abstract: Decentralized, digital health studies can provide real-world evidence of the lasting effects of COVID-19 on physical, socioeconomic, psychological, and social determinant factors of health in India. Existing…
Read MoreCertain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease.
Link: https://doi.org/S0085-2538(23)00559-8 Authors: Claus, Laura R; Chen, Chuan; Stallworth, Jennifer; Turner, Joshua L; Slaats, Gisela G; Hawks, Alexandra L; Mabillard, Holly; Senum, Sarah R; Srikanth, Sujata; Flanagan-Steet, Heather; Louie, Raymond J; Silver, Josh; Lerner-Ellis, Jordan; Morel, Chantal; Mighton, Chloe; Sleutels, Frank; van Slegtenhorst, Marjon; van Ham, Tjakko; Brooks, Alice S; Dorresteijn, Eiske M; Barakat, Tahsin…
Read MoreDigital health and acute kidney injury: consensus report of the 27th Acute Disease Quality Initiative workgroup.
Link: https://doi.org/10.1038/s41581-023-00744-7 Authors: Kashani, Kianoush B; Awdishu, Linda; Bagshaw, Sean M; Barreto, Erin F; Claure-Del Granado, Rolando; Evans, Barbara J; Forni, Lui G; Ghosh, Erina; Goldstein, Stuart L; Kane-Gill, Sandra L; Koola, Jejo; Koyner, Jay L; Liu, Mei; Murugan, Raghavan; Nadkarni, Girish N; Neyra, Javier A; Ninan, Jacob; Ostermann, Marlies; Pannu, Neesh; Rashidi, Parisa; Ronco,…
Read MoreA study of gene expression in the living human brain.
Link: https://doi.org/10.1101/2023.04.21.23288916 Authors: Liharska, Lora E; Park, You Jeong; Ziafat, Kimia; Wilkins, Lillian; Silk, Hannah; Linares, Lisa M; Vornholt, Eric; Sullivan, Brendan; Cohen, Vanessa; Kota, Prashant; Feng, Claudia; Cheng, Esther; Moya, Emily; Thompson, Ryan C; Johnson, Jessica S; Rieder, Marysia-Kolbe; Huang, Jia; Scarpa, Joseph; Hashemi, Alice; Polanco, Jairo; Levin, Matthew A; Nadkarni, Girish N; Sebra,…
Read MoreTime-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus.
Link: https://doi.org/10.1101/2023.07.25.23293180 Authors: Kwak, Soo Heon; Hernandez-Cancela, Ryan B; DiCorpo, Daniel A; Condon, David E; Merino, Jordi; Wu, Peitao; Brody, Jennifer A; Yao, Jie; Guo, Xiuqing; Ahmadizar, Fariba; Meyer, Mariah; Sincan, Murat; Mercader, Josep M; Lee, Sujin; Haessler, Jeffrey; Vy, Ha My T; Lin, Zhaotong; Armstrong, Nicole D; Gu, Shaopeng; Tsao, Noah L; Lange, Leslie…
Read MoreA Novel ECG-Based Deep Learning Algorithm to Predict Cardiomyopathy in Patients With Premature Ventricular Complexes.
Link: https://doi.org/S2405-500X(23)00339-0 Authors: Lampert, Joshua; Vaid, Akhil; Whang, William; Koruth, Jacob; Miller, Marc A; Langan, Marie-Noelle; Musikantow, Daniel; Turagam, Mohit; Maan, Abhishek; Kawamura, Iwanari; Dukkipati, Srinivas; Nadkarni, Girish N; Reddy, Vivek Y Abstract: Premature ventricular complexes (PVCs) are prevalent and, although often benign, they may lead to PVC-induced cardiomyopathy. We created a deep-learning algorithm to…
Read MoreReversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells.
Link: https://doi.org/10.1007/s00125-023-05960-1 Authors: Shah, Ruchi; Spektor, Tanya M; Weisenberger, Daniel J; Ding, Hui; Patil, Rameshwar; Amador, Cynthia; Song, Xue-Ying; Chun, Steven T; Inzalaco, Jake; Turjman, Sue; Ghiam, Sean; Jeong-Kim, Jiho; Tolstoff, Sasha; Yampolsky, Sabina V; Sawant, Onkar B; Rabinowitz, Yaron S; Maguen, Ezra; Hamrah, Pedram; Svendsen, Clive N; Saghizadeh, Mehrnoosh; Ljubimova, Julia Y; Kramerov, Andrei…
Read MoreDiscrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation.
Link: https://doi.org/S0939-4753(23)00283-1 Authors: Kittrell, Hannah D; DiMenna, Fred J; Arad, Avigdor D; Oh, Wonsuk; Hofer, Ira; Walker, Ryan W; Loos, Ruth J F; Albu, Jeanine B; Nadkarni, Girish N Abstract: Our results indicate that estimated “fat-burning” heart rate zones are inappropriate for prescribing exercise to elicit MLO and we recommend direct individual exercise lipid oxidation…
Read More