4research
Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients.
Link: https://doi.org/10.2215/CJN.10640918 Authors: Chauhan, Kinsuk; Pattharanitima, Pattharawin; Patel, Niralee; Duffy, Aine; Saha, Aparna; Chaudhary, Kumardeep; Debnath, Neha; Van Vleck, Tielman; Chan, Lili; Nadkarni, Girish N; Coca, Steven G Abstract: Hypernatremia is common in hospitalized, critically ill patients. Although there are no clear guidelines on sodium correction rate for hypernatremia, some studies suggest a reduction rate…
Read MoreAdiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.
Link: https://doi.org/10.1136/bmj.k5301 Authors: Chang, Alex R; Grams, Morgan E; Ballew, Shoshana H; Bilo, Henk; Correa, Adolfo; Evans, Marie; Gutierrez, Orlando M; Hosseinpanah, Farhad; Iseki, Kunitoshi; Kenealy, Timothy; Klein, Barbara; Kronenberg, Florian; Lee, Brian J; Li, Yuanying; Miura, Katsuyuki; Navaneethan, Sankar D; Roderick, Paul J; Valdivielso, Jose M; Visseren, Frank L J; Zhang, Luxia; Gansevoort, Ron…
Read MorePatient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response.
Link: https://doi.org/S1934-5909(18)30554-X Authors: Hu, Wenxiang; Jiang, Chunjie; Guan, Dongyin; Dierickx, Pieterjan; Zhang, Rong; Moscati, Arden; Nadkarni, Girish N; Steger, David J; Loos, Ruth J F; Hu, Cheng; Jia, Weiping; Soccio, Raymond E; Lazar, Mitchell A Abstract: Thiazolidinedione drugs (TZDs) target the transcriptional activity of peroxisome proliferator activated receptor γ (PPARγ) to reverse insulin resistance in…
Read MoreChange in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies.
Link: https://doi.org/S2213-8587(18)30313-9 Authors: Coresh, Josef; Heerspink, Hiddo J L; Sang, Yingying; Matsushita, Kunihiro; Arnlov, Johan; Astor, Brad C; Black, Corri; Brunskill, Nigel J; Carrero, Juan-Jesus; Feldman, Harold I; Fox, Caroline S; Inker, Lesley A; Ishani, Areef; Ito, Sadayoshi; Jassal, Simerjot; Konta, Tsuneo; Polkinghorne, Kevan; Romundstad, Solfrid; Solbu, Marit D; Stempniewicz, Nikita; Stengel, Benedicte; Tonelli, Marcello;…
Read MoreTrans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
Link: https://doi.org/10.1038/s41467-018-07867-7 Authors: Morris, Andrew P; Le, Thu H; Wu, Haojia; Akbarov, Artur; van der Most, Peter J; Hemani, Gibran; Smith, George Davey; Mahajan, Anubha; Gaulton, Kyle J; Nadkarni, Girish N; Valladares-Salgado, Adan; Wacher-Rodarte, Niels; Mychaleckyj, Josyf C; Dueker, Nicole D; Guo, Xiuqing; Hai, Yang; Haessler, Jeffrey; Kamatani, Yoichiro; Stilp, Adrienne M; Zhu, Gu; Cook,…
Read MorePlasma endostatin predicts kidney outcomes in patients with type 2 diabetes.
Link: https://doi.org/S0085-2538(18)30772-5 Authors: Chauhan, Kinsuk; Verghese, Divya Anna; Rao, Veena; Chan, Lili; Parikh, Chirag R; Coca, Steven G; Nadkarni, Girish N Abstract:
Read MoreFecal microbiota analysis of polycystic kidney disease patients according to renal function: A pilot study.
Link: https://doi.org/10.1177/1535370218818175 Authors: Yacoub, Rabi; Nadkarni, Girish N; McSkimming, Daniel I; Chaves, Lee D; Abyad, Sham; Bryniarski, Mark A; Honan, Amanda M; Thomas, Shruthi A; Gowda, Madan; He, John C; Uribarri, Jaime Abstract: The heterogeneity of the renal disease, therapeutic interventions, and the original cause of the renal failure, all directly affect the microbiota. We…
Read MoreAssociation of Central Venous Oxygen Saturation Variability and Mortality in Hemodialysis Patients.
Link: https://doi.org/10.1159/000494630 Authors: Zhang, Hanjie; Campos, Israel; Chan, Lili; Meyring-Wösten, Anna; Tapia Silva, Leticia M; Rivera Fuentes, Lemuel; Preciado, Priscila; Thijssen, Stephan; Kooman, Jeroen P; van der Sande, Frank M; Kotanko, Peter Abstract: Central venous oxygen saturation (ScvO2) is correlated with cardiac output. In most patients, ScvO2 declines during hemodialysis (HD) due to factors such…
Read MoreIncreased mortality, morbidities, and costs after heart transplantation in heterotaxy syndrome and other complex situs arrangements.
Link: https://doi.org/S0022-5223(18)32970-2 Authors: Duong, Son Q; Godown, Justin; Soslow, Jonathan H; Thurm, Cary; Hall, Matt; Sainathan, Sandeep; Morell, Victor O; Dodd, Debra A; Feingold, Brian Abstract: Identify pediatric heart transplant (HT) recipients with heterotaxy and other complex arrangements of cardiac situs (heterotaxy/situs anomaly) and compare mortality, morbidities, length of stay (LOS), and costs to recipients…
Read MoreKidney Biopsy-Related Complications in Hospitalized Patients with Acute Kidney Disease.
Link: https://doi.org/10.2215/CJN.04910418 Authors: Moledina, Dennis G; Luciano, Randy L; Kukova, Lidiya; Chan, Lili; Saha, Aparna; Nadkarni, Girish; Alfano, Sandra; Wilson, F Perry; Perazella, Mark A; Parikh, Chirag R Abstract: Patients are informed of the risk of kidney biopsy-related complications using data from nonhospitalized patients, which may underestimate the risk for hospitalized patients. We evaluated the…
Read More